Basic Information
ID: ALA4836715
Type: Binding
Description: Inhibition of 5-LOX in human PMNL assessed as reduction in 5-LOX product formation preincubated for 10 mins before addition of AA and A23187 and measured after 10 mins by RP-HPLC method
Organism: Homo sapiens
Cell type: PMNL
Activity Charts
Bioactivity
Activity Types for Assay ALA4836715
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 460.70 | 7.90 | 7.90 |
| 442.64 | 6.24 | 6.24 |
| 428.61 | 5.93 | 5.93 |
| 426.60 | 7.05 | 7.05 |
| 440.62 | 7.36 | 7.36 |
| 454.65 | 7.67 | 7.67 |
| 344.45 | 4.93 | 4.93 |
| 456.67 | 6.55 | 6.55 |
| 522.68 | 6.53 | 6.53 |
| 620.83 | 8.51 | 8.51 |
| 442.64 | 7.44 | 7.44 |
| 511.75 | 6.52 | 6.52 |
| 428.61 | 7.13 | 7.13 |
| 540.79 | 7.17 | 7.17 |
| 618.81 | 8.83 | 8.83 |
| 432.65 | 7.29 | 7.29 |
| 456.62 | 5.74 | 5.74 |
| 528.69 | 5.99 | 5.99 |
| 540.79 | 5.68 | 5.68 |
| 386.53 | 6.10 | 6.10 |
| 440.62 | 7.36 | 7.36 |
| 536.71 | 6.84 | 6.84 |
| 412.57 | 6.66 | 6.66 |
| 414.59 | 6.72 | 6.72 |
| 576.77 | 8.71 | 8.71 |
| 360.49 | 4.20 | 4.20 |
| 292.38 | 2.48 | 2.48 |
| 470.65 | 6.05 | 6.05 |
| 456.67 | 7.52 | 7.52 |
| 434.66 | 6.17 | 6.17 |
| 442.64 | 6.24 | 6.24 |
| 442.64 | 7.22 | 7.22 |
| 442.64 | 7.43 | 7.43 |
| 525.77 | 6.91 | 6.91 |
| 498.66 | 6.92 | 6.92 |
| 440.62 | 7.36 | 7.36 |
| 485.67 | 5.09 | 5.09 |
| 527.75 | 5.76 | 5.76 |
| 485.71 | 5.99 | 5.99 |
| 652.96 | 5.42 | 5.42 |
| 591.75 | 8.09 | 8.09 |
| 276.33 | 3.21 | 3.21 |
| 462.63 | 4.09 | 4.09 |
| 290.36 | 3.60 | 3.60 |
| 483.69 | 7.11 | 7.11 |
| 662.86 | 9.24 | 9.24 |
| 552.71 | 6.51 | 6.51 |