Basic Information
ID: ALA4837101
Type: Binding
Description: Inhibition of recombinant his-tagged KRAS G12D mutant (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition of GDP-GTP exchange rate in presence of recombinant SOS1/GMPPNP incubated for 1 hr by BODIPY fluorescence assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4837101
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 640.57 | 4.16 | 4.16 |
| 545.63 | 5.10 | 5.10 |
| 597.53 | 4.02 | 4.02 |
| 570.74 | 3.64 | 3.64 |
| 682.61 | 3.93 | 3.93 |
| 635.61 | 4.09 | 4.09 |
| 637.60 | 4.80 | 4.80 |
| 684.60 | 4.65 | 4.65 |
| 629.55 | 4.57 | 4.57 |