Basic Information
ID: ALA4839743
Type: ADME
Description: Activation of full length human PXR expressed in human HepG2 cells co-expressing luciferase of CYP3A4 promoter transcription assessed as increase of luciferase activity at 50 uM preincubated for 24 hrs followed by addition of luciferase substrate and measured by hPXR Gene reporter assay relative to control
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HepG2
Target: Pregnane X receptor(ALA3401)
Document: ALA4837255
Activation of full length human PXR expressed in human HepG2 cells co-expressing luciferase of CYP3A4 promoter transcription assessed as increase of luciferase activity at 50 uM preincubated for 24 hrs followed by addition of luciferase substrate and measured by hPXR Gene reporter assay relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4839743
Emax
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 421.50 | 4.74 | 4.74 |
| 404.51 | 6.12 | 6.12 |
| 420.51 | 5.34 | 5.34 |
| 482.58 | 6.70 | 6.70 |
| 414.48 | 4.90 | 4.90 |
| 497.60 | 6.41 | 6.41 |
| 436.51 | 4.53 | 4.53 |
| 483.57 | 6.10 | 6.10 |