Basic Information
ID: ALA4839744
Type: ADME
Description: Activation of full length human PXR expressed in human HepG2 cells co-expressing luciferase of CYP3A4 promoter transcription assessed as increase of luciferase activity preincubated for 24 hrs followed by addition of luciferase substrate and measured by hPXR Gene reporter assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HepG2
Target: Pregnane X receptor(ALA3401)
Document: ALA4837255
Activation of full length human PXR expressed in human HepG2 cells co-expressing luciferase of CYP3A4 promoter transcription assessed as increase of luciferase activity preincubated for 24 hrs followed by addition of luciferase substrate and measured by hPXR Gene reporter assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4839744
EC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 421.50 | 4.74 | 4.74 |
| 404.51 | 6.12 | 6.12 |
| 420.51 | 5.34 | 5.34 |
| 482.58 | 6.70 | 6.70 |
| 414.48 | 4.90 | 4.90 |
| 497.60 | 6.41 | 6.41 |
| 436.51 | 4.53 | 4.53 |
| 483.57 | 6.10 | 6.10 |