Basic Information
ID: ALA4839806
Type: ADME
Description: Ratio of of free drug concentration in mouse brain to EC90 for modulation of gamma secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight by ELISA
Format: BAO_0000219
Target: ADMET(ALA612558)
Document: ALA4837257
Ratio of of free drug concentration in mouse brain to EC90 for modulation of gamma secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight by ELISA: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4839806
Ratio
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 389.42 | 3.35 | 3.35 |
| 423.90 | 4.04 | 4.04 |
| 415.86 | 3.79 | 3.79 |
| 417.39 | 3.63 | 3.63 |
| 418.28 | 3.91 | 3.91 |
| 397.87 | 3.57 | 3.57 |
| 397.87 | 3.65 | 3.65 |
| 418.28 | 3.91 | 3.91 |
| 435.38 | 3.76 | 3.76 |
| 383.84 | 3.26 | 3.26 |
| 401.83 | 3.40 | 3.40 |
| 401.83 | 3.40 | 3.40 |