Basic Information
ID: ALA4840573
Type: Binding
Description: Inhibition of C-terminal 6His-tagged human PDE4D catalytic domain (244 to 578 residues) expressed in Escherichia coli BL21(DE3) pLysS cells assessed as reduction in 5'-AMP formation using cAMP as substrate by NADPH-coupled assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4840573
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 390.48 | 3.00 | 3.00 |
| 390.48 | 2.33 | 2.33 |
| 392.50 | 2.45 | 2.45 |
| 376.45 | 2.62 | 2.62 |
| 404.51 | 2.46 | 2.46 |
| 390.48 | 2.74 | 2.74 |
| 404.51 | 3.39 | 3.39 |
| 402.49 | 2.67 | 2.67 |
| 390.48 | 3.01 | 3.01 |
| 418.53 | 3.78 | 3.78 |
| 418.53 | 3.11 | 3.11 |
| 406.52 | 2.57 | 2.57 |
| 420.55 | 3.23 | 3.23 |
| 416.52 | 3.32 | 3.32 |
| 388.46 | 2.54 | 2.54 |