Basic Information
ID: ALA4843091
Type: Binding
Description: Inhibition of P-gp in human A549/Taxol cells assessed as increase in rhodamine 123 accumulation at 0.5 uM preincubated for 4 hrs followed by addition of rhodamine 123 and measured after 1 hr by flow cytometry assay (Rvb = 26.5%)
Format: BAO_0000219
Organism: Homo sapiens
Cell type: A549/Taxol
Target: P-glycoprotein 1(ALA4302)
Document: ALA4842337
Inhibition of P-gp in human A549/Taxol cells assessed as increase in rhodamine 123 accumulation at 0.5 uM preincubated for 4 hrs followed by addition of rhodamine 123 and measured after 1 hr by flow cytometry assay (Rvb = 26.5%): 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4843091
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 450.62 | 6.70 | 6.70 |
| 877.17 | 9.17 | 9.17 |
| 849.12 | 8.39 | 8.39 |