Basic Information
ID: ALA4843799
Type: Binding
Description: Inhibition of BRD4 in human whole blood assessed as reduction in LPS-induced IL-6 secretion preincubated for 30 mins followed by LPS stimulation and measured after 24 hrs by MSD assay
Format: BAO_0000221
Organism: Homo sapiens
Tissue: Blood
Target: Bromodomain-containing protein 4(ALA1163125)
Document: ALA4842350
Inhibition of BRD4 in human whole blood assessed as reduction in LPS-induced IL-6 secretion preincubated for 30 mins followed by LPS stimulation and measured after 24 hrs by MSD assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4843799
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 423.90 | 3.66 | 3.66 |
| 415.45 | 4.16 | 4.16 |
| 432.52 | 5.17 | 5.17 |
| 490.60 | 5.75 | 5.75 |
| 450.54 | 4.97 | 4.97 |
| 477.57 | 4.13 | 4.13 |
| 435.53 | 4.36 | 4.36 |
| 458.52 | 4.37 | 4.37 |
| 472.55 | 4.93 | 4.93 |
| 450.54 | 4.97 | 4.97 |
| 450.54 | 4.97 | 4.97 |