Assay Report Card

Basic Information

ID: ALA4844502

Type: Binding

Description: Inhibition of Zika virus recombinant NS2B (47 to 95 residues)/NS3 (1 to 177 residues) protease expressed in Escherichia coli BL21 using Bz-Nle-Lys-Lys-Arg-AMC as substrate preincubated for 10 mins by fluorescence-based biochemical assay

Organism: Zika virus

Activity Charts

Bioactivity

Activity Types for Assay ALA4844502

IC50

Total(73)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
338.46	2.27	2.27
418.54	3.40	3.40
339.46	3.63	3.63
514.76	6.12	6.12
320.40	2.71	2.71
389.54	4.86	4.86
417.56	2.97	2.97
358.45	3.44	3.44
320.40	2.71	2.71
405.54	7.91	7.91
402.54	4.16	4.16
358.45	3.44	3.44
351.43	3.70	3.70
334.42	2.96	2.96
431.58	3.95	3.95
389.54	4.86	4.86
389.54	4.86	4.86
334.42	2.96	2.96
363.46	3.06	3.06
430.60	4.55	4.55
310.35	3.17	3.17
372.47	3.74	3.74
334.42	2.96	2.96
392.57	5.35	5.35
362.48	3.02	3.02
402.42	3.98	3.98
430.60	4.55	4.55
416.57	4.55	4.55
376.50	4.88	4.88
334.42	2.96	2.96
334.42	2.96	2.96
392.57	5.35	5.35
335.41	2.35	2.35
362.48	3.02	3.02
368.87	3.61	3.61
390.53	4.26	4.26
323.40	2.29	2.29
333.44	3.56	3.56
323.40	3.16	3.16
417.43	4.46	4.46
415.56	5.29	5.29
377.49	3.10	3.10
389.45	4.42	4.42
417.56	2.97	2.97
423.51	3.59	3.59
507.72	7.58	7.58
361.45	3.38	3.38
425.53	5.36	5.36
409.53	5.23	5.23
416.57	4.55	4.55
433.56	2.79	2.79
323.40	2.29	2.29
334.42	2.96	2.96
363.46	3.57	3.57
344.42	3.19	3.19
358.45	3.44	3.44
348.45	3.35	3.35
390.53	4.26	4.26
323.40	2.29	2.29
351.43	3.70	3.70
339.44	2.70	2.70
409.49	3.34	3.34
399.49	4.82	4.82
362.48	3.02	3.02
376.46	2.66	2.66
351.43	3.70	3.70
347.46	3.87	3.87
389.54	4.86	4.86
345.40	3.45	3.45
369.42	3.84	3.84
351.43	3.70	3.70
257.34	1.90	1.90
416.57	7.72	7.72