Basic Information
ID: ALA4844502
Type: Binding
Description: Inhibition of Zika virus recombinant NS2B (47 to 95 residues)/NS3 (1 to 177 residues) protease expressed in Escherichia coli BL21 using Bz-Nle-Lys-Lys-Arg-AMC as substrate preincubated for 10 mins by fluorescence-based biochemical assay
Format: BAO_0000019
Organism: Zika virus
Target: Genome polyprotein(ALA4523954)
Document: ALA4842369
Inhibition of Zika virus recombinant NS2B (47 to 95 residues)/NS3 (1 to 177 residues) protease expressed in Escherichia coli BL21 using Bz-Nle-Lys-Lys-Arg-AMC as substrate preincubated for 10 mins by fluorescence-based biochemical assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4844502
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 338.46 | 2.27 | 2.27 |
| 418.54 | 3.40 | 3.40 |
| 339.46 | 3.63 | 3.63 |
| 514.76 | 6.12 | 6.12 |
| 320.40 | 2.71 | 2.71 |
| 389.54 | 4.86 | 4.86 |
| 417.56 | 2.97 | 2.97 |
| 358.45 | 3.44 | 3.44 |
| 320.40 | 2.71 | 2.71 |
| 405.54 | 7.91 | 7.91 |
| 402.54 | 4.16 | 4.16 |
| 358.45 | 3.44 | 3.44 |
| 351.43 | 3.70 | 3.70 |
| 334.42 | 2.96 | 2.96 |
| 431.58 | 3.95 | 3.95 |
| 389.54 | 4.86 | 4.86 |
| 389.54 | 4.86 | 4.86 |
| 334.42 | 2.96 | 2.96 |
| 363.46 | 3.06 | 3.06 |
| 430.60 | 4.55 | 4.55 |
| 310.35 | 3.17 | 3.17 |
| 372.47 | 3.74 | 3.74 |
| 334.42 | 2.96 | 2.96 |
| 392.57 | 5.35 | 5.35 |
| 362.48 | 3.02 | 3.02 |
| 402.42 | 3.98 | 3.98 |
| 430.60 | 4.55 | 4.55 |
| 416.57 | 4.55 | 4.55 |
| 376.50 | 4.88 | 4.88 |
| 334.42 | 2.96 | 2.96 |
| 334.42 | 2.96 | 2.96 |
| 392.57 | 5.35 | 5.35 |
| 335.41 | 2.35 | 2.35 |
| 362.48 | 3.02 | 3.02 |
| 368.87 | 3.61 | 3.61 |
| 390.53 | 4.26 | 4.26 |
| 323.40 | 2.29 | 2.29 |
| 333.44 | 3.56 | 3.56 |
| 323.40 | 3.16 | 3.16 |
| 417.43 | 4.46 | 4.46 |
| 415.56 | 5.29 | 5.29 |
| 377.49 | 3.10 | 3.10 |
| 389.45 | 4.42 | 4.42 |
| 417.56 | 2.97 | 2.97 |
| 423.51 | 3.59 | 3.59 |
| 507.72 | 7.58 | 7.58 |
| 361.45 | 3.38 | 3.38 |
| 425.53 | 5.36 | 5.36 |
| 409.53 | 5.23 | 5.23 |
| 416.57 | 4.55 | 4.55 |
| 433.56 | 2.79 | 2.79 |
| 323.40 | 2.29 | 2.29 |
| 334.42 | 2.96 | 2.96 |
| 363.46 | 3.57 | 3.57 |
| 344.42 | 3.19 | 3.19 |
| 358.45 | 3.44 | 3.44 |
| 348.45 | 3.35 | 3.35 |
| 390.53 | 4.26 | 4.26 |
| 323.40 | 2.29 | 2.29 |
| 351.43 | 3.70 | 3.70 |
| 339.44 | 2.70 | 2.70 |
| 409.49 | 3.34 | 3.34 |
| 399.49 | 4.82 | 4.82 |
| 362.48 | 3.02 | 3.02 |
| 376.46 | 2.66 | 2.66 |
| 351.43 | 3.70 | 3.70 |
| 347.46 | 3.87 | 3.87 |
| 389.54 | 4.86 | 4.86 |
| 345.40 | 3.45 | 3.45 |
| 369.42 | 3.84 | 3.84 |
| 351.43 | 3.70 | 3.70 |
| 257.34 | 1.90 | 1.90 |
| 416.57 | 7.72 | 7.72 |