Basic Information
ID: ALA4845546
Type: Binding
Description: Inhibition of GDP-loaded His-tagged KRAS G12C mutant (2 to 182 residues) (unknown origin) assessed as inhibition of SOS1-catalyzed nucleotide exchange preincubated for 1 hr followed by SOS1 addition measured after 1 hr by TR-FRET assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4845546
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 684.00 | 6.48 | 6.48 |
| 694.00 | 6.55 | 6.55 |
| 654.96 | 6.27 | 6.27 |
| 615.11 | 5.17 | 5.17 |
| 694.00 | 6.55 | 6.55 |
| 668.99 | 6.66 | 6.66 |
| 683.01 | 7.04 | 7.04 |
| 571.06 | 5.38 | 5.38 |