Basic Information
ID: ALA4845547
Type: Binding
Description: Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 2 hrs by HTRF assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: NCI-H358
Target: GTPase KRas(ALA2189121)
Document: ALA4842392
Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 2 hrs by HTRF assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4845547
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 684.00 | 6.48 | 6.48 |
| 694.00 | 6.55 | 6.55 |
| 654.96 | 6.27 | 6.27 |
| 615.11 | 5.17 | 5.17 |
| 694.00 | 6.55 | 6.55 |
| 668.99 | 6.66 | 6.66 |
| 683.01 | 7.04 | 7.04 |
| 571.06 | 5.38 | 5.38 |