Basic Information
ID: ALA5033586
Type: Binding
Description: Inhibition of human topoisomerase I using DNA pBR322 as substrate assessed as DNA relaxation incubated for 45 mins by ethidium bromide staining based agarose gel electrophoresis
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5033586
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 421.45 | 1.85 | 1.85 |
| 261.71 | 4.09 | 4.09 |
| 282.35 | 4.96 | 4.96 |
| 352.82 | 5.34 | 5.34 |
| 386.37 | 5.71 | 5.71 |
| 360.46 | 4.80 | 4.80 |
| 318.38 | 4.69 | 4.69 |
| 402.44 | 6.42 | 6.42 |
| 396.87 | 5.66 | 5.66 |
| 367.84 | 5.05 | 5.05 |
| 346.43 | 5.31 | 5.31 |
| 346.43 | 4.41 | 4.41 |
| 426.90 | 5.67 | 5.67 |
| 366.85 | 5.65 | 5.65 |
| 387.36 | 5.10 | 5.10 |
| 396.87 | 5.66 | 5.66 |
| 400.36 | 5.43 | 5.43 |
| 416.40 | 5.72 | 5.72 |
| 380.83 | 5.37 | 5.37 |
| 332.40 | 4.37 | 4.37 |
| 332.40 | 4.56 | 4.56 |
| 446.43 | 5.73 | 5.73 |
| 376.46 | 5.32 | 5.32 |