Basic Information
ID: ALA5037545
Type: ADME
Description: Inhibition of CYP3A4 in human liver microsomes using ketoconazole as substrate incubated for 5 mins in presence of NADPH by LC-MS/MS analysis
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsomes
Activity Charts
Bioactivity
Activity Types for Assay ALA5037545
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 512.57 | 5.51 | 5.51 |
| 508.62 | 3.57 | 3.57 |
| 689.86 | 5.87 | 5.87 |
| 705.86 | 4.98 | 4.98 |
| 731.90 | 5.07 | 5.07 |
| 706.90 | 5.07 | 5.07 |
| 717.92 | 6.20 | 6.20 |
| 661.85 | 6.09 | 6.09 |
| 717.92 | 5.54 | 5.54 |
| 720.88 | 4.59 | 4.59 |
| 715.90 | 5.95 | 5.95 |
| 704.88 | 5.48 | 5.48 |
| 727.91 | 5.95 | 5.95 |
| 687.89 | 6.18 | 6.18 |
| 676.87 | 5.70 | 5.70 |
| 675.84 | 5.17 | 5.17 |
| 664.81 | 4.70 | 4.70 |
| 649.80 | 5.09 | 5.09 |
| 691.88 | 5.46 | 5.46 |