ID: ALA5038474
Type: Binding
Description: Inhibition of NLRP3 inflammasome activation in LPS/nigericin-treated human THP-1 cells assessed as reduction in pyroptosis in LPS stimulation for 3 hrs followed by pretreatment for 40 min before induced with nigericin for 40 min by propidium iodide staining based inverted microscopic assay
Format: BAO_0000221
Organism: Homo sapiens
Cell type: THP-1
Target: NACHT, LRR and PYD domains-containing protein 3(ALA1741208)
Document: ALA5036380
Inhibition of NLRP3 inflammasome activation in LPS/nigericin-treated human THP-1 cells assessed as reduction in pyroptosis in LPS stimulation for 3 hrs followed by pretreatment for 40 min before induced with nigericin for 40 min by propidium iodide staining based inverted microscopic assay: 1
Bioactivity
Activity Types for Assay ALA5038474
Inhibition
Parent Molecular Weight | ALogP | Polar Surface Area |
---|---|---|
365.20 | 4.50 | 4.50 |