Basic Information
ID: ALA5038513
Type: Functional
Description: Antiinflammatory activity in human THP-1 cells assessed as inhibition of LPS-induced IL-1beta secretion in LPS stimulation for 3 hrs followed by pretreatment at 2uM for 40 min before induced with nigericin for 40 min measured by ELISA
Format: BAO_0000219
Organism: Homo sapiens
Cell type: THP-1
Target: THP-1(ALA614245)
Document: ALA5036380
Antiinflammatory activity in human THP-1 cells assessed as inhibition of LPS-induced IL-1beta secretion in LPS stimulation for 3 hrs followed by pretreatment at 2uM for 40 min before induced with nigericin for 40 min measured by ELISA: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA5038513
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 308.33 | 4.35 | 4.35 |
| 404.49 | 2.99 | 2.99 |
| 308.33 | 4.35 | 4.35 |
| 326.32 | 4.49 | 4.49 |
| 376.33 | 5.36 | 5.36 |
| 405.45 | 3.64 | 3.64 |
| 417.26 | 4.33 | 4.33 |
| 343.77 | 4.39 | 4.39 |
| 359.38 | 4.89 | 4.89 |
| 379.41 | 3.11 | 3.11 |
| 387.23 | 5.11 | 5.11 |
| 337.38 | 4.17 | 4.17 |
| 398.38 | 5.68 | 5.68 |
| 455.51 | 4.78 | 4.78 |
| 405.37 | 5.19 | 5.19 |
| 309.32 | 3.74 | 3.74 |
| 300.33 | 4.05 | 4.05 |
| 391.45 | 5.47 | 5.47 |
| 393.41 | 4.81 | 4.81 |
| 272.30 | 3.44 | 3.44 |
| 388.22 | 4.50 | 4.50 |
| 355.37 | 4.31 | 4.31 |
| 352.37 | 4.13 | 4.13 |
| 396.85 | 6.06 | 6.06 |
| 365.20 | 4.50 | 4.50 |
| 341.34 | 4.24 | 4.24 |
| 297.31 | 3.67 | 3.67 |
| 323.35 | 4.10 | 4.10 |
| 378.35 | 5.28 | 5.28 |
| 323.35 | 3.93 | 3.93 |
| 310.35 | 4.27 | 4.27 |
| 398.41 | 4.37 | 4.37 |
| 377.32 | 4.76 | 4.76 |
| 376.33 | 5.36 | 5.36 |
| 286.30 | 3.74 | 3.74 |
| 368.43 | 5.47 | 5.47 |
| 403.23 | 4.26 | 4.26 |
| 390.23 | 4.42 | 4.42 |
| 352.36 | 5.00 | 5.00 |
| 328.34 | 4.40 | 4.40 |
| 323.35 | 3.93 | 3.93 |
| 326.32 | 4.49 | 4.49 |
| 323.35 | 3.93 | 3.93 |
| 333.34 | 4.22 | 4.22 |
| 298.29 | 3.94 | 3.94 |
| 248.23 | 2.55 | 2.55 |
| 326.32 | 4.49 | 4.49 |
| 324.33 | 4.05 | 4.05 |
| 391.35 | 5.12 | 5.12 |
| 385.42 | 5.41 | 5.41 |
| 340.39 | 5.16 | 5.16 |
| 376.43 | 5.71 | 5.71 |
| 322.36 | 4.65 | 4.65 |
| 440.49 | 4.81 | 4.81 |