Basic Information
ID: ALA5041626
Type: Binding
Description: Inhibition of 5-LO in A23187-stimulated human HEK293 cells assessed as reduction in 5-LO product level at 1 uM preincubated for 5 mins followed by A23187, arachidonic acid addition and measured after 15 mins by RP-HPLC analysis relative to control
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HEK293
Target: Arachidonate 5-lipoxygenase(ALA215)
Document: ALA5038646
Inhibition of 5-LO in A23187-stimulated human HEK293 cells assessed as reduction in 5-LO product level at 1 uM preincubated for 5 mins followed by A23187, arachidonic acid addition and measured after 15 mins by RP-HPLC analysis relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA5041626
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 236.30 | 2.73 | 2.73 |
| 238.24 | 1.60 | 1.60 |
| 252.27 | 1.99 | 1.99 |
| 342.39 | 3.51 | 3.51 |
| 312.37 | 3.50 | 3.50 |
| 342.39 | 3.60 | 3.60 |
| 328.36 | 3.21 | 3.21 |
| 370.40 | 3.43 | 3.43 |
| 342.39 | 3.52 | 3.52 |
| 338.36 | 3.55 | 3.55 |
| 358.39 | 3.22 | 3.22 |
| 396.36 | 4.23 | 4.23 |
| 316.35 | 2.74 | 2.74 |
| 314.38 | 3.54 | 3.54 |
| 342.39 | 3.52 | 3.52 |
| 330.38 | 3.13 | 3.13 |
| 262.26 | 1.60 | 1.60 |
| 300.35 | 3.64 | 3.64 |
| 346.35 | 3.35 | 3.35 |
| 312.37 | 3.50 | 3.50 |
| 328.41 | 4.07 | 4.07 |
| 266.29 | 2.38 | 2.38 |
| 327.38 | 2.78 | 2.78 |
| 396.36 | 4.23 | 4.23 |
| 358.39 | 3.22 | 3.22 |
| 312.37 | 3.50 | 3.50 |
| 342.39 | 3.52 | 3.52 |
| 346.35 | 3.35 | 3.35 |
| 302.33 | 2.81 | 2.81 |
| 352.39 | 3.75 | 3.75 |
| 334.41 | 3.94 | 3.94 |
| 346.35 | 3.35 | 3.35 |
| 312.36 | 3.62 | 3.62 |
| 358.39 | 3.22 | 3.22 |
| 396.36 | 4.23 | 4.23 |
| 266.29 | 2.37 | 2.37 |