Basic Information
ID: ALA5051022
Type: Binding
Description: Inhibition of human TREX1 exonuclease activity using labeled DNA oligonucleotide as substrate incubated for 30 mins and measured after 45 mins by fluorescence assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5051022
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 590.55 | 3.07 | 3.07 |
| 591.54 | 3.49 | 3.49 |
| 624.54 | 3.02 | 3.02 |
| 582.02 | 4.66 | 4.66 |
| 600.06 | 4.82 | 4.82 |
| 547.48 | 3.09 | 3.09 |
| 600.55 | 3.80 | 3.80 |
| 527.15 | 3.91 | 3.91 |
| 597.93 | 3.58 | 3.58 |
| 577.51 | 3.31 | 3.31 |
| 675.65 | 5.00 | 5.00 |
| 610.07 | 5.26 | 5.26 |
| 611.59 | 3.78 | 3.78 |
| 618.56 | 3.93 | 3.93 |
| 561.68 | 2.50 | 2.50 |
| 631.96 | 3.15 | 3.15 |
| 527.15 | 3.66 | 3.66 |
| 577.60 | 4.01 | 4.01 |
| 616.57 | 3.81 | 3.81 |
| 595.15 | 4.71 | 4.71 |
| 582.02 | 4.66 | 4.66 |
| 632.03 | 4.56 | 4.56 |
| 662.04 | 2.76 | 2.76 |
| 585.54 | 2.76 | 2.76 |
| 624.05 | 4.84 | 4.84 |
| 575.54 | 4.23 | 4.23 |
| 682.67 | 3.09 | 3.09 |
| 629.99 | 3.71 | 3.71 |
| 527.15 | 3.40 | 3.40 |
| 606.53 | 4.06 | 4.06 |
| 636.58 | 2.89 | 2.89 |
| 624.52 | 2.11 | 2.11 |
| 643.62 | 3.55 | 3.55 |
| 575.50 | 2.92 | 2.92 |
| 560.62 | 3.19 | 3.19 |
| 582.02 | 4.66 | 4.66 |
| 525.48 | 4.34 | 4.34 |
| 570.01 | 4.52 | 4.52 |
| 491.89 | 3.05 | 3.05 |
| 513.13 | 3.35 | 3.35 |
| 633.57 | 4.27 | 4.27 |
| 595.06 | 3.84 | 3.84 |
| 515.10 | 2.14 | 2.14 |
| 605.52 | 2.55 | 2.55 |
| 665.62 | 3.97 | 3.97 |
| 615.57 | 2.77 | 2.77 |
| 599.11 | 4.51 | 4.51 |
| 558.08 | 1.52 | 1.52 |
| 618.56 | 3.11 | 3.11 |
| 581.47 | 3.06 | 3.06 |
| 565.46 | 1.71 | 1.71 |
| 642.51 | 2.48 | 2.48 |
| 539.04 | 3.35 | 3.35 |
| 588.54 | 3.92 | 3.92 |
| 574.51 | 3.53 | 3.53 |
| 632.05 | 3.50 | 3.50 |
| 581.47 | 3.06 | 3.06 |
| 520.14 | 2.81 | 2.81 |
| 615.60 | 4.92 | 4.92 |
| 603.53 | 2.90 | 2.90 |
| 596.99 | 2.88 | 2.88 |
| 617.60 | 3.39 | 3.39 |
| 608.06 | 3.89 | 3.89 |
| 627.01 | 3.35 | 3.35 |
| 601.58 | 4.53 | 4.53 |
| 611.59 | 3.78 | 3.78 |
| 565.56 | 4.15 | 4.15 |
| 665.62 | 3.97 | 3.97 |
| 596.04 | 4.70 | 4.70 |
| 691.65 | 4.24 | 4.24 |
| 541.05 | 2.27 | 2.27 |
| 605.56 | 3.88 | 3.88 |
| 591.54 | 3.49 | 3.49 |
| 659.64 | 3.79 | 3.79 |
| 583.99 | 4.11 | 4.11 |
| 618.07 | 4.32 | 4.32 |
| 600.55 | 3.80 | 3.80 |
| 632.05 | 3.85 | 3.85 |
| 538.14 | 3.22 | 3.22 |
| 575.54 | 3.57 | 3.57 |
| 596.49 | 2.48 | 2.48 |
| 547.49 | 1.88 | 1.88 |
| 520.14 | 2.81 | 2.81 |
| 567.99 | 4.27 | 4.27 |
| 689.68 | 5.39 | 5.39 |
| 579.50 | 3.62 | 3.62 |
| 661.63 | 4.74 | 4.74 |
| 547.57 | 4.01 | 4.01 |
| 577.51 | 3.23 | 3.23 |
| 561.60 | 4.31 | 4.31 |
| 549.11 | 3.63 | 3.63 |
| 578.54 | 2.31 | 2.31 |
| 597.93 | 3.58 | 3.58 |
| 562.50 | 2.87 | 2.87 |
| 593.51 | 2.93 | 2.93 |
| 561.51 | 3.48 | 3.48 |
| 527.15 | 3.91 | 3.91 |
| 555.93 | 2.61 | 2.61 |
| 646.62 | 3.53 | 3.53 |
| 561.51 | 3.73 | 3.73 |
| 519.17 | 3.73 | 3.73 |
| 581.12 | 4.37 | 4.37 |
| 528.05 | 2.22 | 2.22 |
| 616.46 | 5.31 | 5.31 |
| 664.58 | 3.44 | 3.44 |
| 596.04 | 5.00 | 5.00 |
| 563.16 | 2.54 | 2.54 |
| 531.12 | 3.49 | 3.49 |
| 625.05 | 2.88 | 2.88 |
| 575.54 | 4.23 | 4.23 |
| 603.59 | 4.35 | 4.35 |
| 597.93 | 3.58 | 3.58 |
| 592.52 | 2.49 | 2.49 |
| 567.99 | 4.27 | 4.27 |
| 589.56 | 3.96 | 3.96 |
| 575.54 | 4.12 | 4.12 |
| 547.57 | 4.01 | 4.01 |
| 588.54 | 3.87 | 3.87 |
| 656.63 | 2.55 | 2.55 |
| 582.02 | 4.77 | 4.77 |
| 547.57 | 4.01 | 4.01 |
| 636.58 | 3.35 | 3.35 |
| 562.50 | 2.87 | 2.87 |
| 635.04 | 3.67 | 3.67 |
| 608.50 | 3.50 | 3.50 |
| 543.15 | 3.36 | 3.36 |
| 581.47 | 3.06 | 3.06 |
| 563.48 | 2.92 | 2.92 |
| 575.54 | 4.12 | 4.12 |
| 615.57 | 5.03 | 5.03 |
| 542.70 | 2.48 | 2.48 |
| 616.06 | 3.83 | 3.83 |
| 576.53 | 2.90 | 2.90 |
| 561.68 | 2.50 | 2.50 |
| 579.50 | 3.62 | 3.62 |
| 561.51 | 3.48 | 3.48 |
| 608.50 | 3.50 | 3.50 |
| 674.67 | 3.81 | 3.81 |
| 653.58 | 4.10 | 4.10 |
| 653.58 | 4.10 | 4.10 |
| 620.58 | 3.14 | 3.14 |
| 600.59 | 4.70 | 4.70 |
| 620.58 | 3.14 | 3.14 |
| 627.64 | 5.11 | 5.11 |
| 617.57 | 3.76 | 3.76 |
| 619.59 | 4.27 | 4.27 |