Basic Information
ID: ALA5051143
Type: Binding
Description: Inhibition of recombinant His-tagged human KIF18A (1 to 467 residues) expressed in baculovirus expression system assessed as inhibition of microtubule-stimulated ATPase activity preincubated for 15 mins followed by ATP addition and further incubated for 15 mins and measured after 40 mins by ADP-Glo reagent based assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5051143
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 478.64 | 4.14 | 4.14 |
| 508.67 | 3.91 | 3.91 |
| 508.67 | 3.64 | 3.64 |
| 492.67 | 4.53 | 4.53 |
| 520.68 | 3.60 | 3.60 |
| 515.06 | 3.78 | 3.78 |
| 546.69 | 2.34 | 2.34 |
| 520.68 | 4.01 | 4.01 |
| 508.67 | 3.91 | 3.91 |
| 485.61 | 2.74 | 2.74 |
| 481.60 | 2.52 | 2.52 |
| 544.72 | 3.68 | 3.68 |
| 521.54 | 2.69 | 2.69 |
| 509.66 | 2.46 | 2.46 |
| 508.67 | 3.91 | 3.91 |
| 571.62 | 2.93 | 2.93 |
| 494.64 | 3.25 | 3.25 |
| 564.61 | 2.89 | 2.89 |
| 524.67 | 2.62 | 2.62 |
| 571.62 | 2.93 | 2.93 |
| 480.61 | 3.13 | 3.13 |
| 486.60 | 1.98 | 1.98 |
| 494.64 | 3.52 | 3.52 |
| 509.66 | 3.30 | 3.30 |
| 482.63 | 3.47 | 3.47 |
| 530.70 | 3.37 | 3.37 |
| 591.66 | 2.70 | 2.70 |
| 510.64 | 3.14 | 3.14 |
| 454.58 | 2.70 | 2.70 |
| 493.66 | 3.04 | 3.04 |
| 524.67 | 2.88 | 2.88 |
| 556.61 | 3.35 | 3.35 |
| 508.67 | 3.84 | 3.84 |
| 494.64 | 3.25 | 3.25 |
| 515.64 | 2.41 | 2.41 |
| 461.56 | 3.33 | 3.33 |
| 500.63 | 2.71 | 2.71 |
| 516.59 | 3.11 | 3.11 |
| 492.62 | 3.27 | 3.27 |
| 524.67 | 3.14 | 3.14 |
| 494.64 | 3.52 | 3.52 |
| 505.54 | 3.72 | 3.72 |
| 495.63 | 2.91 | 2.91 |
| 510.64 | 2.49 | 2.49 |
| 538.69 | 3.27 | 3.27 |
| 547.68 | 1.74 | 1.74 |
| 535.57 | 3.08 | 3.08 |
| 477.61 | 4.10 | 4.10 |
| 517.65 | 2.39 | 2.39 |
| 508.67 | 3.83 | 3.83 |
| 494.64 | 3.52 | 3.52 |
| 505.62 | 3.19 | 3.19 |
| 505.62 | 3.00 | 3.00 |
| 531.68 | 2.76 | 2.76 |
| 519.69 | 3.58 | 3.58 |
| 495.63 | 2.83 | 2.83 |
| 549.64 | 3.68 | 3.68 |
| 530.65 | 2.07 | 2.07 |
| 511.63 | 2.01 | 2.01 |
| 555.61 | 2.85 | 2.85 |
| 505.54 | 3.72 | 3.72 |
| 499.64 | 2.88 | 2.88 |
| 593.77 | 4.79 | 4.79 |
| 478.60 | 3.42 | 3.42 |
| 496.66 | 3.78 | 3.78 |
| 494.64 | 3.52 | 3.52 |
| 517.65 | 2.39 | 2.39 |
| 611.69 | 4.73 | 4.73 |
| 535.57 | 3.08 | 3.08 |
| 557.68 | 3.32 | 3.32 |
| 543.69 | 2.86 | 2.86 |
| 508.67 | 3.64 | 3.64 |
| 534.66 | 4.19 | 4.19 |
| 508.67 | 3.56 | 3.56 |
| 510.64 | 2.41 | 2.41 |
| 506.61 | 2.40 | 2.40 |
| 499.64 | 2.80 | 2.80 |
| 520.63 | 4.07 | 4.07 |
| 507.64 | 3.45 | 3.45 |
| 494.64 | 3.52 | 3.52 |
| 490.40 | 3.03 | 3.03 |
| 464.61 | 3.89 | 3.89 |
| 480.61 | 3.13 | 3.13 |
| 521.62 | 3.46 | 3.46 |
| 494.64 | 3.52 | 3.52 |
| 508.67 | 3.64 | 3.64 |
| 511.63 | 2.53 | 2.53 |
| 561.61 | 4.49 | 4.49 |
| 555.62 | 3.96 | 3.96 |
| 534.62 | 4.58 | 4.58 |
| 494.64 | 3.44 | 3.44 |
| 462.55 | 3.95 | 3.95 |
| 494.64 | 3.25 | 3.25 |
| 493.66 | 3.22 | 3.22 |
| 507.68 | 3.48 | 3.48 |
| 511.63 | 1.88 | 1.88 |
| 571.62 | 2.93 | 2.93 |
| 542.71 | 3.41 | 3.41 |
| 522.69 | 4.15 | 4.15 |
| 508.67 | 3.91 | 3.91 |
| 479.63 | 4.19 | 4.19 |
| 507.68 | 3.43 | 3.43 |
| 499.59 | 2.48 | 2.48 |
| 492.62 | 3.13 | 3.13 |
| 533.72 | 3.97 | 3.97 |
| 529.67 | 2.52 | 2.52 |
| 607.80 | 5.13 | 5.13 |
| 521.71 | 3.82 | 3.82 |
| 521.54 | 2.69 | 2.69 |
| 508.67 | 3.91 | 3.91 |
| 535.57 | 2.81 | 2.81 |
| 505.54 | 3.72 | 3.72 |
| 493.61 | 2.66 | 2.66 |
| 500.63 | 2.24 | 2.24 |
| 479.63 | 3.53 | 3.53 |
| 505.54 | 3.72 | 3.72 |
| 508.67 | 4.17 | 4.17 |
| 526.64 | 1.46 | 1.46 |
| 506.65 | 4.06 | 4.06 |
| 555.62 | 3.96 | 3.96 |
| 510.64 | 2.49 | 2.49 |
| 508.67 | 3.91 | 3.91 |
| 481.60 | 2.53 | 2.53 |
| 521.54 | 2.69 | 2.69 |
| 481.60 | 2.53 | 2.53 |
| 393.49 | 2.95 | 2.95 |
| 555.62 | 3.96 | 3.96 |
| 469.56 | 3.34 | 3.34 |
| 500.59 | 4.14 | 4.14 |
| 517.65 | 2.39 | 2.39 |
| 513.66 | 3.44 | 3.44 |
| 516.05 | 3.18 | 3.18 |
| 520.68 | 3.68 | 3.68 |
| 535.64 | 2.34 | 2.34 |
| 476.63 | 3.75 | 3.75 |
| 481.60 | 2.53 | 2.53 |
| 494.64 | 3.52 | 3.52 |
| 528.68 | 2.76 | 2.76 |
| 541.68 | 2.62 | 2.62 |
| 521.67 | 3.40 | 3.40 |
| 480.61 | 2.86 | 2.86 |
| 579.75 | 4.35 | 4.35 |
| 468.58 | 3.45 | 3.45 |
| 496.61 | 2.10 | 2.10 |
| 535.57 | 3.08 | 3.08 |
| 508.67 | 3.64 | 3.64 |
| 512.63 | 3.66 | 3.66 |
| 499.64 | 2.62 | 2.62 |
| 548.61 | 4.06 | 4.06 |