Basic Information
ID: ALA5051594
Type: Binding
Description: Inhibition of recombinant His-tagged human KIF18A (1 to 467 residues) expressed in baculovirus expression system assessed as inhibition of microtubule-stimulated ATPase activity preincubated for 15 mins followed by ATP addition and further incubated for 15 mins and measured after 40 mins by ADP-Glo reagent based assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5051594
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 556.61 | 4.17 | 4.17 |
| 556.61 | 4.17 | 4.17 |
| 542.58 | 3.32 | 3.32 |
| 505.59 | 3.85 | 3.85 |
| 529.66 | 2.21 | 2.21 |
| 529.66 | 2.59 | 2.59 |
| 539.70 | 4.23 | 4.23 |
| 549.64 | 3.68 | 3.68 |
| 511.65 | 3.09 | 3.09 |
| 573.71 | 5.55 | 5.55 |
| 543.69 | 3.06 | 3.06 |
| 514.65 | 2.71 | 2.71 |
| 540.69 | 3.50 | 3.50 |
| 542.58 | 3.78 | 3.78 |
| 526.70 | 4.51 | 4.51 |
| 533.65 | 4.63 | 4.63 |
| 541.72 | 4.02 | 4.02 |
| 504.61 | 2.21 | 2.21 |
| 542.70 | 3.48 | 3.48 |
| 543.69 | 2.98 | 2.98 |
| 483.64 | 3.97 | 3.97 |
| 531.65 | 3.92 | 3.92 |
| 523.70 | 4.82 | 4.82 |
| 549.64 | 3.60 | 3.60 |
| 563.67 | 3.99 | 3.99 |
| 545.66 | 4.63 | 4.63 |
| 528.68 | 3.16 | 3.16 |
| 535.71 | 5.00 | 5.00 |
| 498.65 | 4.24 | 4.24 |
| 535.62 | 3.29 | 3.29 |
| 575.68 | 4.40 | 4.40 |
| 543.67 | 4.14 | 4.14 |
| 554.67 | 2.55 | 2.55 |
| 563.67 | 4.07 | 4.07 |
| 557.72 | 3.37 | 3.37 |
| 509.68 | 4.51 | 4.51 |
| 561.66 | 3.74 | 3.74 |
| 528.68 | 3.01 | 3.01 |
| 483.64 | 3.97 | 3.97 |
| 441.60 | 4.42 | 4.42 |
| 523.70 | 4.82 | 4.82 |
| 555.72 | 5.34 | 5.34 |
| 498.65 | 3.40 | 3.40 |
| 509.68 | 4.51 | 4.51 |
| 557.72 | 3.45 | 3.45 |
| 541.72 | 3.75 | 3.75 |
| 524.59 | 3.48 | 3.48 |
| 574.65 | 3.56 | 3.56 |
| 567.63 | 4.24 | 4.24 |
| 529.66 | 2.67 | 2.67 |
| 514.65 | 3.63 | 3.63 |
| 541.67 | 3.08 | 3.08 |
| 543.69 | 3.06 | 3.06 |
| 513.66 | 3.70 | 3.70 |
| 559.68 | 5.16 | 5.16 |
| 558.58 | 2.75 | 2.75 |
| 513.64 | 4.17 | 4.17 |
| 528.68 | 3.32 | 3.32 |
| 563.67 | 3.99 | 3.99 |
| 555.70 | 3.01 | 3.01 |
| 531.63 | 4.46 | 4.46 |
| 543.69 | 3.06 | 3.06 |
| 564.71 | 3.47 | 3.47 |
| 563.67 | 3.53 | 3.53 |
| 549.64 | 3.60 | 3.60 |
| 556.61 | 4.09 | 4.09 |
| 577.70 | 4.38 | 4.38 |
| 547.65 | 2.81 | 2.81 |
| 498.65 | 3.48 | 3.48 |
| 517.63 | 2.99 | 2.99 |
| 534.63 | 4.27 | 4.27 |
| 526.66 | 3.11 | 3.11 |
| 570.63 | 4.48 | 4.48 |
| 526.66 | 2.59 | 2.59 |
| 525.72 | 5.14 | 5.14 |
| 531.63 | 4.38 | 4.38 |
| 531.65 | 3.65 | 3.65 |
| 515.63 | 5.05 | 5.05 |
| 548.71 | 4.75 | 4.75 |
| 548.71 | 4.75 | 4.75 |
| 520.68 | 3.19 | 3.19 |
| 512.68 | 4.54 | 4.54 |
| 569.73 | 3.32 | 3.32 |
| 532.66 | 2.91 | 2.91 |
| 535.62 | 3.21 | 3.21 |
| 512.68 | 4.12 | 4.12 |
| 517.63 | 2.99 | 2.99 |
| 553.73 | 3.97 | 3.97 |
| 549.64 | 3.95 | 3.95 |
| 518.64 | 2.60 | 2.60 |
| 557.72 | 2.99 | 2.99 |
| 518.64 | 2.60 | 2.60 |
| 573.71 | 5.41 | 5.41 |
| 529.66 | 2.67 | 2.67 |
| 535.62 | 3.90 | 3.90 |
| 543.69 | 2.98 | 2.98 |
| 557.72 | 2.99 | 2.99 |
| 543.68 | 5.83 | 5.83 |
| 550.69 | 3.08 | 3.08 |
| 553.73 | 4.22 | 4.22 |
| 555.75 | 4.06 | 4.06 |
| 563.67 | 4.07 | 4.07 |
| 499.64 | 3.31 | 3.31 |
| 553.73 | 4.36 | 4.36 |
| 559.68 | 5.24 | 5.24 |
| 535.69 | 3.16 | 3.16 |
| 559.68 | 5.24 | 5.24 |
| 533.65 | 4.63 | 4.63 |
| 553.73 | 4.22 | 4.22 |
| 525.68 | 3.48 | 3.48 |
| 581.66 | 4.63 | 4.63 |
| 532.66 | 2.99 | 2.99 |
| 543.69 | 3.06 | 3.06 |
| 510.66 | 4.80 | 4.80 |
| 539.70 | 3.97 | 3.97 |
| 557.72 | 3.37 | 3.37 |
| 529.66 | 2.59 | 2.59 |
| 470.60 | 2.95 | 2.95 |
| 543.69 | 2.96 | 2.96 |
| 549.72 | 3.65 | 3.65 |
| 539.70 | 3.97 | 3.97 |
| 427.57 | 4.24 | 4.24 |
| 553.73 | 4.36 | 4.36 |
| 543.69 | 2.60 | 2.60 |
| 545.66 | 4.77 | 4.77 |
| 484.62 | 3.34 | 3.34 |
| 545.66 | 4.77 | 4.77 |
| 572.61 | 3.06 | 3.06 |
| 555.70 | 3.21 | 3.21 |
| 498.65 | 3.22 | 3.22 |
| 525.72 | 5.14 | 5.14 |
| 529.66 | 2.39 | 2.39 |
| 553.61 | 4.20 | 4.20 |
| 547.63 | 3.62 | 3.62 |
| 597.66 | 3.69 | 3.69 |
| 572.61 | 3.14 | 3.14 |
| 545.66 | 4.85 | 4.85 |
| 542.70 | 3.48 | 3.48 |
| 589.71 | 4.52 | 4.52 |
| 517.63 | 3.61 | 3.61 |
| 652.61 | 3.79 | 3.79 |
| 499.64 | 2.85 | 2.85 |
| 525.68 | 3.33 | 3.33 |
| 547.67 | 5.02 | 5.02 |
| 562.68 | 5.05 | 5.05 |
| 496.54 | 3.05 | 3.05 |
| 530.65 | 2.86 | 2.86 |
| 522.59 | 5.61 | 5.61 |
| 543.68 | 5.83 | 5.83 |
| 541.72 | 3.94 | 3.94 |
| 543.69 | 2.98 | 2.98 |
| 541.69 | 4.95 | 4.95 |
| 557.72 | 2.99 | 2.99 |
| 515.64 | 2.28 | 2.28 |
| 555.70 | 3.21 | 3.21 |
| 555.70 | 3.21 | 3.21 |
| 539.70 | 4.23 | 4.23 |
| 577.70 | 4.38 | 4.38 |
| 573.71 | 5.55 | 5.55 |
| 522.59 | 5.61 | 5.61 |
| 539.70 | 3.97 | 3.97 |
| 523.70 | 5.00 | 5.00 |
| 553.73 | 4.36 | 4.36 |
| 575.73 | 5.80 | 5.80 |
| 425.55 | 4.00 | 4.00 |
| 514.65 | 3.01 | 3.01 |
| 541.72 | 4.48 | 4.48 |
| 443.57 | 3.35 | 3.35 |
| 515.63 | 5.05 | 5.05 |
| 550.63 | 3.08 | 3.08 |
| 569.73 | 3.55 | 3.55 |
| 592.17 | 6.36 | 6.36 |
| 543.69 | 2.98 | 2.98 |
| 535.62 | 3.29 | 3.29 |
| 527.69 | 4.01 | 4.01 |