Basic Information
ID: ALA5051731
Type: Binding
Description: Inhibition of recombinant His-tagged human KIF18A (1 to 467 residues) expressed in baculovirus expression system assessed as inhibition of microtubule-stimulated ATPase activity preincubated for 15 mins followed by ATP addition and further incubated for 15 mins and measured after 40 mins by ADP-Glo reagent based assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5051731
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 534.70 | 3.77 | 3.77 |
| 562.76 | 4.55 | 4.55 |
| 566.65 | 4.43 | 4.43 |
| 548.66 | 4.29 | 4.29 |
| 534.70 | 3.30 | 3.30 |
| 440.59 | 4.94 | 4.94 |
| 424.57 | 4.60 | 4.60 |
| 575.75 | 3.96 | 3.96 |
| 548.73 | 4.26 | 4.26 |
| 575.80 | 5.11 | 5.11 |
| 578.76 | 3.52 | 3.52 |
| 578.76 | 3.52 | 3.52 |
| 564.73 | 2.67 | 2.67 |
| 440.57 | 4.05 | 4.05 |
| 513.66 | 3.61 | 3.61 |
| 574.77 | 4.69 | 4.69 |
| 548.73 | 3.65 | 3.65 |
| 500.67 | 3.80 | 3.80 |
| 528.68 | 3.28 | 3.28 |
| 521.69 | 4.80 | 4.80 |
| 548.73 | 4.26 | 4.26 |
| 560.74 | 3.94 | 3.94 |
| 562.68 | 4.60 | 4.60 |
| 560.69 | 3.71 | 3.71 |
| 564.73 | 3.13 | 3.13 |
| 546.67 | 3.42 | 3.42 |
| 435.55 | 4.27 | 4.27 |
| 542.70 | 3.57 | 3.57 |
| 576.74 | 3.07 | 3.07 |
| 424.52 | 4.47 | 4.47 |
| 546.67 | 3.42 | 3.42 |
| 506.65 | 3.09 | 3.09 |
| 533.72 | 3.94 | 3.94 |
| 521.69 | 4.80 | 4.80 |
| 576.79 | 4.94 | 4.94 |
| 560.74 | 4.30 | 4.30 |
| 520.68 | 3.04 | 3.04 |
| 560.74 | 3.79 | 3.79 |
| 547.74 | 4.33 | 4.33 |
| 528.68 | 3.12 | 3.12 |
| 517.65 | 3.20 | 3.20 |
| 512.68 | 4.04 | 4.04 |
| 526.70 | 4.80 | 4.80 |
| 506.65 | 3.09 | 3.09 |
| 519.69 | 3.80 | 3.80 |
| 546.72 | 4.01 | 4.01 |
| 592.78 | 3.45 | 3.45 |
| 515.68 | 3.60 | 3.60 |
| 574.77 | 4.23 | 4.23 |
| 548.73 | 4.16 | 4.16 |
| 426.58 | 4.85 | 4.85 |
| 556.73 | 3.90 | 3.90 |
| 528.72 | 4.58 | 4.58 |
| 542.70 | 3.46 | 3.46 |
| 449.58 | 4.58 | 4.58 |
| 521.69 | 4.80 | 4.80 |
| 498.65 | 3.76 | 3.76 |
| 546.67 | 3.42 | 3.42 |
| 511.69 | 4.68 | 4.68 |
| 515.68 | 3.60 | 3.60 |
| 469.61 | 3.56 | 3.56 |
| 546.72 | 4.01 | 4.01 |
| 525.67 | 3.76 | 3.76 |
| 440.61 | 5.02 | 5.02 |
| 508.64 | 5.05 | 5.05 |
| 560.74 | 3.84 | 3.84 |
| 544.69 | 4.94 | 4.94 |