Basic Information
ID: ALA5051732
Type: Binding
Description: Inhibition of recombinant His-tagged human KIF18A (1 to 467 residues) expressed in baculovirus expression system assessed as inhibition of microtubule-stimulated ATPase activity preincubated for 15 mins followed by ATP addition and further incubated for 15 mins and measured after 40 mins by ADP-Glo reagent based assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5051732
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 515.61 | 3.79 | 3.79 |
| 563.67 | 4.25 | 4.25 |
| 544.72 | 3.76 | 3.76 |
| 546.74 | 3.86 | 3.86 |
| 558.75 | 4.15 | 4.15 |
| 544.72 | 3.76 | 3.76 |
| 528.68 | 2.53 | 2.53 |
| 527.69 | 4.01 | 4.01 |
| 532.71 | 3.61 | 3.61 |
| 555.62 | 3.96 | 3.96 |
| 518.68 | 3.22 | 3.22 |
| 548.69 | 3.51 | 3.51 |
| 572.65 | 3.77 | 3.77 |
| 542.71 | 3.47 | 3.47 |
| 532.71 | 3.61 | 3.61 |
| 516.67 | 2.98 | 2.98 |
| 544.72 | 3.61 | 3.61 |
| 546.69 | 2.34 | 2.34 |
| 540.64 | 3.22 | 3.22 |
| 515.68 | 3.86 | 3.86 |
| 563.67 | 4.25 | 4.25 |
| 530.70 | 3.37 | 3.37 |
| 539.70 | 4.78 | 4.78 |
| 527.69 | 4.01 | 4.01 |
| 555.62 | 3.96 | 3.96 |
| 542.71 | 3.47 | 3.47 |
| 525.68 | 3.76 | 3.76 |
| 544.72 | 3.68 | 3.68 |
| 560.77 | 4.25 | 4.25 |
| 482.63 | 3.47 | 3.47 |
| 580.70 | 4.00 | 4.00 |
| 480.61 | 3.13 | 3.13 |
| 574.75 | 3.39 | 3.39 |
| 565.62 | 4.67 | 4.67 |
| 548.71 | 2.85 | 2.85 |
| 548.69 | 3.51 | 3.51 |
| 546.74 | 4.01 | 4.01 |
| 525.68 | 4.22 | 4.22 |
| 560.77 | 4.25 | 4.25 |
| 528.68 | 3.12 | 3.12 |
| 569.65 | 4.41 | 4.41 |
| 532.07 | 4.31 | 4.31 |