ID: ALA5051761
Type: Binding
Description: Inhibition of METTL3 (unknown origin) using UCUGGACUAAA-biotin and 3H-SAM as substrates preincubated for 5 mins followed by substrate addition incubated for 30 mins by TopCount scintillation counting method
Organism: Homo sapiens
Bioactivity
Activity Types for Assay ALA5051761
IC50
Parent Molecular Weight | ALogP | Polar Surface Area |
---|---|---|
404.47 | 2.06 | 2.06 |
504.59 | 3.35 | 3.35 |
520.57 | 3.30 | 3.30 |
502.54 | 1.70 | 1.70 |
531.55 | 3.41 | 3.41 |
516.54 | 2.63 | 2.63 |
504.52 | 3.85 | 3.85 |
521.55 | 2.15 | 2.15 |
448.53 | 2.01 | 2.01 |
460.54 | 2.41 | 2.41 |
518.55 | 2.78 | 2.78 |
540.57 | 3.59 | 3.59 |
476.54 | 2.39 | 2.39 |
483.37 | 2.82 | 2.82 |
500.65 | 4.57 | 4.57 |
456.89 | 1.96 | 1.96 |
480.50 | 1.94 | 1.94 |
493.50 | 2.79 | 2.79 |
404.47 | 2.06 | 2.06 |
504.59 | 3.03 | 3.03 |
355.40 | 0.62 | 0.62 |
465.49 | 1.38 | 1.38 |
429.50 | 1.79 | 1.79 |
474.57 | 3.99 | 3.99 |
508.63 | 4.13 | 4.13 |
394.44 | 1.10 | 1.10 |
432.48 | 2.50 | 2.50 |
404.47 | 2.06 | 2.06 |
510.56 | 2.74 | 2.74 |
575.63 | 1.68 | 1.68 |
491.48 | 2.93 | 2.93 |
520.57 | 3.30 | 3.30 |
545.58 | 1.88 | 1.88 |
440.89 | 2.98 | 2.98 |
489.31 | 2.58 | 2.58 |
460.54 | 2.52 | 2.52 |
560.59 | 1.93 | 1.93 |
423.43 | 0.70 | 0.70 |
542.60 | 2.89 | 2.89 |
420.47 | 1.81 | 1.81 |
390.45 | 1.87 | 1.87 |
408.42 | 0.84 | 0.84 |
530.56 | 2.94 | 2.94 |
504.53 | 2.96 | 2.96 |
464.50 | 3.16 | 3.16 |
432.53 | 2.54 | 2.54 |
422.45 | 1.15 | 1.15 |
557.59 | 2.85 | 2.85 |
339.40 | 1.32 | 1.32 |
586.67 | 4.05 | 4.05 |
494.53 | 3.13 | 3.13 |
458.57 | 3.08 | 3.08 |
432.53 | 2.83 | 2.83 |
406.45 | 1.51 | 1.51 |
487.31 | 1.60 | 1.60 |
446.56 | 3.30 | 3.30 |
501.52 | 3.34 | 3.34 |
494.56 | 3.08 | 3.08 |
349.41 | 1.39 | 1.39 |
377.45 | 2.41 | 2.41 |
442.43 | 2.42 | 2.42 |
510.60 | 3.56 | 3.56 |
438.46 | 2.59 | 2.59 |
492.52 | 2.53 | 2.53 |
546.56 | 1.82 | 1.82 |
532.58 | 3.24 | 3.24 |
507.57 | 2.70 | 2.70 |
428.49 | 2.89 | 2.89 |
482.59 | 4.12 | 4.12 |
436.47 | 1.61 | 1.61 |
488.59 | 3.51 | 3.51 |
432.53 | 2.83 | 2.83 |
545.58 | 2.02 | 2.02 |
446.56 | 3.01 | 3.01 |
474.57 | 3.99 | 3.99 |
458.88 | 2.93 | 2.93 |
396.45 | 1.42 | 1.42 |
492.43 | 3.30 | 3.30 |
378.44 | 1.81 | 1.81 |
493.50 | 2.01 | 2.01 |
521.60 | 3.09 | 3.09 |
494.53 | 3.26 | 3.26 |
436.47 | 1.61 | 1.61 |
568.68 | 4.10 | 4.10 |
532.58 | 3.72 | 3.72 |
418.50 | 2.37 | 2.37 |
485.34 | 2.94 | 2.94 |
436.49 | 2.66 | 2.66 |
528.59 | 4.05 | 4.05 |
510.60 | 3.45 | 3.45 |
436.47 | 1.33 | 1.33 |
517.52 | 3.10 | 3.10 |
406.45 | 1.40 | 1.40 |
462.51 | 2.03 | 2.03 |
527.59 | 1.84 | 1.84 |
491.53 | 2.27 | 2.27 |
512.57 | 2.91 | 2.91 |
531.55 | 2.61 | 2.61 |
517.36 | 3.14 | 3.14 |
485.34 | 3.09 | 3.09 |
528.55 | 2.90 | 2.90 |
369.43 | 1.33 | 1.33 |
559.61 | 3.02 | 3.02 |
491.55 | 2.08 | 2.08 |
489.58 | 3.88 | 3.88 |
530.56 | 2.85 | 2.85 |
518.55 | 3.16 | 3.16 |
482.59 | 3.88 | 3.88 |
494.60 | 4.09 | 4.09 |
554.38 | 3.40 | 3.40 |
390.45 | 1.87 | 1.87 |
548.58 | 2.07 | 2.07 |
378.44 | 1.81 | 1.81 |
478.53 | 3.23 | 3.23 |
492.56 | 3.94 | 3.94 |
498.55 | 2.68 | 2.68 |
448.53 | 1.88 | 1.88 |
504.53 | 2.68 | 2.68 |
559.56 | 1.88 | 1.88 |
494.53 | 3.13 | 3.13 |
545.58 | 1.78 | 1.78 |
526.62 | 4.07 | 4.07 |
408.42 | 0.84 | 0.84 |
403.49 | 2.66 | 2.66 |
495.58 | 4.06 | 4.06 |
494.49 | 2.27 | 2.27 |
503.33 | 2.89 | 2.89 |
536.51 | 4.22 | 4.22 |
512.57 | 3.26 | 3.26 |
502.62 | 3.41 | 3.41 |
565.61 | 2.17 | 2.17 |
430.51 | 3.05 | 3.05 |
532.58 | 3.72 | 3.72 |
501.52 | 3.34 | 3.34 |
501.34 | 2.06 | 2.06 |
508.63 | 4.12 | 4.12 |
395.49 | 2.54 | 2.54 |
472.59 | 3.72 | 3.72 |
410.48 | 1.68 | 1.68 |
522.65 | 4.44 | 4.44 |
421.50 | 2.28 | 2.28 |
518.55 | 2.99 | 2.99 |
419.49 | 1.56 | 1.56 |
610.67 | 2.12 | 2.12 |
418.50 | 2.37 | 2.37 |
490.56 | 2.96 | 2.96 |
476.54 | 2.25 | 2.25 |
531.55 | 2.24 | 2.24 |
434.50 | 2.25 | 2.25 |
480.57 | 4.22 | 4.22 |
584.53 | 3.65 | 3.65 |
546.56 | 1.91 | 1.91 |
504.53 | 2.68 | 2.68 |
447.50 | 1.44 | 1.44 |
405.46 | 1.54 | 1.54 |
474.57 | 2.56 | 2.56 |
378.44 | 1.81 | 1.81 |
446.56 | 3.30 | 3.30 |
390.45 | 1.87 | 1.87 |
515.55 | 3.65 | 3.65 |
418.50 | 2.37 | 2.37 |
436.47 | 1.69 | 1.69 |
418.50 | 2.52 | 2.52 |
546.61 | 3.27 | 3.27 |
480.34 | 2.51 | 2.51 |
432.48 | 2.86 | 2.86 |
529.58 | 3.91 | 3.91 |
339.40 | 1.32 | 1.32 |
503.33 | 3.04 | 3.04 |
508.58 | 3.29 | 3.29 |
403.49 | 2.66 | 2.66 |
572.64 | 3.80 | 3.80 |
462.51 | 1.86 | 1.86 |
418.50 | 2.52 | 2.52 |
474.57 | 2.56 | 2.56 |
507.57 | 2.51 | 2.51 |
518.35 | 2.62 | 2.62 |
480.50 | 1.53 | 1.53 |
424.44 | 2.28 | 2.28 |
472.91 | 3.32 | 3.32 |
472.59 | 4.65 | 4.65 |
418.50 | 2.52 | 2.52 |
512.57 | 2.90 | 2.90 |
504.59 | 2.98 | 2.98 |
502.34 | 3.65 | 3.65 |
503.32 | 0.85 | 0.85 |
529.37 | 3.46 | 3.46 |
464.50 | 3.20 | 3.20 |
529.58 | 2.80 | 2.80 |
482.47 | 2.07 | 2.07 |
459.55 | 3.27 | 3.27 |
474.57 | 3.45 | 3.45 |
512.59 | 4.04 | 4.04 |
510.60 | 3.58 | 3.58 |
504.59 | 3.35 | 3.35 |
478.28 | 1.91 | 1.91 |
515.55 | 3.65 | 3.65 |
500.65 | 4.57 | 4.57 |
566.54 | 3.70 | 3.70 |
478.51 | 1.10 | 1.10 |
377.45 | 2.41 | 2.41 |
492.54 | 1.74 | 1.74 |
547.59 | 3.00 | 3.00 |
504.53 | 2.68 | 2.68 |
490.50 | 2.67 | 2.67 |
536.59 | 2.91 | 2.91 |
518.59 | 4.10 | 4.10 |
559.61 | 2.54 | 2.54 |
588.64 | 3.04 | 3.04 |
434.50 | 2.36 | 2.36 |
519.58 | 3.00 | 3.00 |
392.46 | 1.89 | 1.89 |
546.56 | 2.71 | 2.71 |
544.59 | 3.60 | 3.60 |
486.62 | 4.18 | 4.18 |
541.41 | 2.62 | 2.62 |
518.55 | 3.07 | 3.07 |
551.58 | 0.72 | 0.72 |
518.55 | 3.07 | 3.07 |
471.49 | 0.32 | 0.32 |
484.56 | 2.46 | 2.46 |
504.53 | 2.68 | 2.68 |