Basic Information
ID: ALA5051762
Type: Binding
Description: Inhibition of PRMT5 (unknown origin) using Ac-SGRGKGGKGLGKGGAKRHRKVGGK-Biotin and 3H-SAM as substrates preincubated for 5 mins followed by substrate addition incubated for 60 mins by TopCount scintillation counting method
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5051762
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 389.46 | 2.48 | 2.48 |
| 404.47 | 2.06 | 2.06 |
| 458.57 | 3.30 | 3.30 |
| 504.59 | 3.35 | 3.35 |
| 502.54 | 1.70 | 1.70 |
| 531.55 | 3.41 | 3.41 |
| 516.54 | 2.63 | 2.63 |
| 504.52 | 3.85 | 3.85 |
| 521.55 | 2.15 | 2.15 |
| 448.53 | 2.01 | 2.01 |
| 460.54 | 2.41 | 2.41 |
| 518.55 | 2.78 | 2.78 |
| 540.57 | 3.59 | 3.59 |
| 476.54 | 2.39 | 2.39 |
| 483.37 | 2.82 | 2.82 |
| 500.65 | 4.57 | 4.57 |
| 456.89 | 1.96 | 1.96 |
| 480.50 | 1.94 | 1.94 |
| 493.50 | 2.79 | 2.79 |
| 404.47 | 2.06 | 2.06 |
| 504.59 | 3.03 | 3.03 |
| 355.40 | 0.62 | 0.62 |
| 465.49 | 1.38 | 1.38 |
| 429.50 | 1.79 | 1.79 |
| 474.57 | 3.99 | 3.99 |
| 508.63 | 4.13 | 4.13 |
| 394.44 | 1.10 | 1.10 |
| 432.48 | 2.50 | 2.50 |
| 389.46 | 2.48 | 2.48 |
| 404.47 | 2.06 | 2.06 |
| 510.56 | 2.74 | 2.74 |
| 491.48 | 2.93 | 2.93 |
| 545.58 | 1.88 | 1.88 |
| 440.89 | 2.98 | 2.98 |
| 388.47 | 3.08 | 3.08 |
| 489.31 | 2.58 | 2.58 |
| 460.54 | 2.52 | 2.52 |
| 560.59 | 1.93 | 1.93 |
| 423.43 | 0.70 | 0.70 |
| 542.60 | 2.89 | 2.89 |
| 420.47 | 1.81 | 1.81 |
| 390.45 | 1.87 | 1.87 |
| 408.42 | 0.84 | 0.84 |
| 530.56 | 2.94 | 2.94 |
| 504.53 | 2.96 | 2.96 |
| 464.50 | 3.16 | 3.16 |
| 432.53 | 2.54 | 2.54 |
| 422.45 | 1.15 | 1.15 |
| 557.59 | 2.85 | 2.85 |
| 339.40 | 1.32 | 1.32 |
| 494.53 | 3.13 | 3.13 |
| 458.57 | 3.08 | 3.08 |
| 432.53 | 2.83 | 2.83 |
| 406.45 | 1.51 | 1.51 |
| 487.31 | 1.60 | 1.60 |
| 446.56 | 3.30 | 3.30 |
| 501.52 | 3.34 | 3.34 |
| 494.56 | 3.08 | 3.08 |
| 446.56 | 3.30 | 3.30 |
| 349.41 | 1.39 | 1.39 |
| 377.45 | 2.41 | 2.41 |
| 442.43 | 2.42 | 2.42 |
| 510.60 | 3.56 | 3.56 |
| 438.46 | 2.59 | 2.59 |
| 492.52 | 2.53 | 2.53 |
| 546.56 | 1.82 | 1.82 |
| 532.58 | 3.24 | 3.24 |
| 507.57 | 2.70 | 2.70 |
| 428.49 | 2.89 | 2.89 |
| 436.47 | 1.61 | 1.61 |
| 488.59 | 3.51 | 3.51 |
| 432.53 | 2.83 | 2.83 |
| 545.58 | 2.02 | 2.02 |
| 446.56 | 3.01 | 3.01 |
| 418.50 | 2.37 | 2.37 |
| 474.57 | 3.99 | 3.99 |
| 458.88 | 2.93 | 2.93 |
| 396.45 | 1.42 | 1.42 |
| 492.43 | 3.30 | 3.30 |
| 378.44 | 1.81 | 1.81 |
| 493.50 | 2.01 | 2.01 |
| 521.60 | 3.09 | 3.09 |
| 494.53 | 3.26 | 3.26 |
| 436.47 | 1.61 | 1.61 |
| 532.58 | 3.72 | 3.72 |
| 418.50 | 2.37 | 2.37 |
| 485.34 | 2.94 | 2.94 |
| 436.49 | 2.66 | 2.66 |
| 528.59 | 4.05 | 4.05 |
| 510.60 | 3.45 | 3.45 |
| 436.47 | 1.33 | 1.33 |
| 517.52 | 3.10 | 3.10 |
| 406.45 | 1.40 | 1.40 |
| 462.51 | 2.03 | 2.03 |
| 527.59 | 1.84 | 1.84 |
| 491.53 | 2.27 | 2.27 |
| 512.57 | 2.91 | 2.91 |
| 531.55 | 2.61 | 2.61 |
| 517.36 | 3.14 | 3.14 |
| 485.34 | 3.09 | 3.09 |
| 528.55 | 2.90 | 2.90 |
| 508.63 | 4.13 | 4.13 |
| 369.43 | 1.33 | 1.33 |
| 559.61 | 3.02 | 3.02 |
| 491.55 | 2.08 | 2.08 |
| 489.58 | 3.88 | 3.88 |
| 530.56 | 2.85 | 2.85 |
| 518.55 | 3.16 | 3.16 |
| 482.59 | 3.88 | 3.88 |
| 494.60 | 4.09 | 4.09 |
| 554.38 | 3.40 | 3.40 |
| 390.45 | 1.87 | 1.87 |
| 548.58 | 2.07 | 2.07 |
| 378.44 | 1.81 | 1.81 |
| 478.53 | 3.23 | 3.23 |
| 492.56 | 3.94 | 3.94 |
| 498.55 | 2.68 | 2.68 |
| 448.53 | 1.88 | 1.88 |
| 468.36 | 3.24 | 3.24 |
| 504.53 | 2.68 | 2.68 |
| 559.56 | 1.88 | 1.88 |
| 494.53 | 3.13 | 3.13 |
| 545.58 | 1.78 | 1.78 |
| 526.62 | 4.07 | 4.07 |
| 408.42 | 0.84 | 0.84 |
| 403.49 | 2.66 | 2.66 |
| 495.58 | 4.06 | 4.06 |
| 494.49 | 2.27 | 2.27 |
| 503.33 | 2.89 | 2.89 |
| 536.51 | 4.22 | 4.22 |
| 512.57 | 3.26 | 3.26 |
| 502.62 | 3.41 | 3.41 |
| 565.61 | 2.17 | 2.17 |
| 430.51 | 3.05 | 3.05 |
| 532.58 | 3.72 | 3.72 |
| 501.52 | 3.34 | 3.34 |
| 501.34 | 2.06 | 2.06 |
| 508.63 | 4.12 | 4.12 |
| 395.49 | 2.54 | 2.54 |
| 472.59 | 3.72 | 3.72 |
| 410.48 | 1.68 | 1.68 |
| 522.65 | 4.44 | 4.44 |
| 421.50 | 2.28 | 2.28 |
| 518.55 | 2.99 | 2.99 |
| 419.49 | 1.56 | 1.56 |
| 610.67 | 2.12 | 2.12 |
| 418.50 | 2.37 | 2.37 |
| 490.56 | 2.96 | 2.96 |
| 476.54 | 2.25 | 2.25 |
| 531.55 | 2.24 | 2.24 |
| 434.50 | 2.25 | 2.25 |
| 480.57 | 4.22 | 4.22 |
| 584.53 | 3.65 | 3.65 |
| 546.56 | 1.91 | 1.91 |
| 504.53 | 2.68 | 2.68 |
| 447.50 | 1.44 | 1.44 |
| 405.46 | 1.54 | 1.54 |
| 474.57 | 2.56 | 2.56 |
| 378.44 | 1.81 | 1.81 |
| 446.56 | 3.30 | 3.30 |
| 390.45 | 1.87 | 1.87 |
| 515.55 | 3.65 | 3.65 |
| 418.50 | 2.37 | 2.37 |
| 436.47 | 1.69 | 1.69 |
| 418.50 | 2.52 | 2.52 |
| 480.34 | 2.51 | 2.51 |
| 432.48 | 2.86 | 2.86 |
| 529.58 | 3.91 | 3.91 |
| 339.40 | 1.32 | 1.32 |
| 503.33 | 3.04 | 3.04 |
| 508.58 | 3.29 | 3.29 |
| 403.49 | 2.66 | 2.66 |
| 462.51 | 1.86 | 1.86 |
| 418.50 | 2.52 | 2.52 |
| 474.57 | 2.56 | 2.56 |
| 507.57 | 2.51 | 2.51 |
| 518.35 | 2.62 | 2.62 |
| 480.50 | 1.53 | 1.53 |
| 424.44 | 2.28 | 2.28 |
| 472.91 | 3.32 | 3.32 |
| 472.59 | 4.65 | 4.65 |
| 418.50 | 2.52 | 2.52 |
| 512.57 | 2.90 | 2.90 |
| 504.59 | 2.98 | 2.98 |
| 502.34 | 3.65 | 3.65 |
| 503.32 | 0.85 | 0.85 |
| 529.37 | 3.46 | 3.46 |
| 464.50 | 3.20 | 3.20 |
| 529.58 | 2.80 | 2.80 |
| 482.47 | 2.07 | 2.07 |
| 459.55 | 3.27 | 3.27 |
| 512.59 | 4.04 | 4.04 |
| 510.60 | 3.58 | 3.58 |
| 504.59 | 3.35 | 3.35 |
| 478.28 | 1.91 | 1.91 |
| 515.55 | 3.65 | 3.65 |
| 500.65 | 4.57 | 4.57 |
| 566.54 | 3.70 | 3.70 |
| 478.51 | 1.10 | 1.10 |
| 377.45 | 2.41 | 2.41 |
| 492.54 | 1.74 | 1.74 |
| 390.45 | 1.87 | 1.87 |
| 547.59 | 3.00 | 3.00 |
| 504.53 | 2.68 | 2.68 |
| 490.50 | 2.67 | 2.67 |
| 536.59 | 2.91 | 2.91 |
| 518.59 | 4.10 | 4.10 |
| 559.61 | 2.54 | 2.54 |
| 434.50 | 2.36 | 2.36 |
| 519.58 | 3.00 | 3.00 |
| 392.46 | 1.89 | 1.89 |
| 546.56 | 2.71 | 2.71 |
| 544.59 | 3.60 | 3.60 |
| 486.62 | 4.18 | 4.18 |
| 541.41 | 2.62 | 2.62 |
| 518.55 | 3.07 | 3.07 |
| 551.58 | 0.72 | 0.72 |
| 518.55 | 3.07 | 3.07 |
| 471.49 | 0.32 | 0.32 |
| 484.56 | 2.46 | 2.46 |
| 504.53 | 2.68 | 2.68 |