Assay Report Card

Basic Information

ID: ALA5051768

Type: Binding

Description: Inhibition of full-length His-tagged METTL3 (unknown origin) coexpressed with full-length FLAG-tagged METTL14 (unknown origin) expressed in baculovirus expression system using 5'P-uacacucgaucuggacuaaagcugcuc-3' RNA as substrate pre-incubated for 10 mins and followed by substrate addition and measured after 60 mins by methyltransferase assay

Organism: Homo sapiens

Activity Charts

Bioactivity

Activity Types for Assay ALA5051768

IC50

Total(151)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
387.44	2.31	2.31
431.50	2.11	2.11
403.44	1.28	1.28
431.50	2.06	2.06
413.48	2.61	2.61
412.50	3.64	3.64
442.52	2.78	2.78
401.47	2.56	2.56
429.52	3.34	3.34
429.40	2.76	2.76
447.49	4.12	4.12
397.49	3.85	3.85
441.54	3.39	3.39
445.57	4.02	4.02
387.49	3.86	3.86
415.50	3.00	3.00
439.52	3.37	3.37
387.44	2.36	2.36
433.49	3.09	3.09
437.45	2.85	2.85
383.46	3.60	3.60
411.51	4.24	4.24
427.51	2.95	2.95
431.50	2.33	2.33
457.53	2.76	2.76
446.49	2.48	2.48
443.55	3.58	3.58
443.55	3.73	3.73
441.54	3.13	3.13
429.52	3.53	3.53
429.52	3.53	3.53
455.56	3.87	3.87
441.54	3.48	3.48
399.45	2.22	2.22
318.34	2.11	2.11
427.51	3.64	3.64
427.51	3.36	3.36
419.46	2.74	2.74
387.49	3.86	3.86
438.54	3.89	3.89
445.50	3.04	3.04
431.50	2.11	2.11
411.51	4.01	4.01
415.50	3.00	3.00
403.49	2.85	2.85
427.51	3.00	3.00
415.50	2.95	2.95
429.52	3.39	3.39
446.49	2.48	2.48
411.51	4.38	4.38
441.54	4.02	4.02
441.54	3.48	3.48
457.51	3.73	3.73
443.51	2.47	2.47
459.55	3.11	3.11
427.51	3.14	3.14
433.49	3.13	3.13
348.36	1.60	1.60
455.57	4.37	4.37
452.52	2.89	2.89
427.51	3.09	3.09
431.50	2.11	2.11
389.50	4.11	4.11
459.55	2.89	2.89
433.49	3.04	3.04
433.49	3.13	3.13
445.52	2.50	2.50
455.44	3.10	3.10
416.49	2.39	2.39
443.55	3.78	3.78
445.50	3.09	3.09
441.54	3.53	3.53
451.53	3.15	3.15
416.49	2.39	2.39
429.52	3.24	3.24
429.52	3.39	3.39
401.47	2.92	2.92
457.53	2.76	2.76
401.47	2.61	2.61
441.54	3.34	3.34
441.51	4.10	4.10
425.49	2.61	2.61
411.51	4.24	4.24
442.50	3.50	3.50
477.53	3.04	3.04
415.50	3.09	3.09
429.52	3.48	3.48
442.52	2.88	2.88
318.34	1.88	1.88
417.51	3.24	3.24
402.50	3.77	3.77
441.54	3.39	3.39
417.51	3.00	3.00
385.43	1.83	1.83
457.53	3.25	3.25
411.51	4.11	4.11
412.50	4.57	4.57
419.53	2.88	2.88
413.48	2.70	2.70
401.47	2.75	2.75
443.55	3.77	3.77
453.55	4.13	4.13
422.54	4.78	4.78
459.53	3.34	3.34
318.34	2.11	2.11
417.47	1.98	1.98
415.50	3.14	3.14
416.49	2.39	2.39
485.47	2.87	2.87
481.60	4.16	4.16
415.48	3.77	3.77
431.93	4.28	4.28
441.54	3.34	3.34
410.53	4.85	4.85
437.50	3.40	3.40
463.49	3.34	3.34
447.49	4.35	4.35
428.50	2.39	2.39
427.51	3.35	3.35
431.50	2.11	2.11
445.52	2.76	2.76
429.52	3.01	3.01
428.50	2.39	2.39
441.54	3.48	3.48
416.49	2.39	2.39
427.51	2.99	2.99
451.48	3.24	3.24
417.47	1.94	1.94
427.51	3.09	3.09
459.53	3.48	3.48
411.51	4.24	4.24
457.53	2.76	2.76
413.48	2.56	2.56
427.51	2.95	2.95
441.54	3.39	3.39
413.48	2.75	2.75
405.43	2.26	2.26
429.52	3.34	3.34
417.47	1.94	1.94
443.55	3.73	3.73
412.50	3.64	3.64
427.51	3.09	3.09
401.47	2.70	2.70
439.52	3.64	3.64
410.52	4.85	4.85
427.51	3.00	3.00
431.50	2.11	2.11
437.45	2.80	2.80
403.49	2.99	2.99
423.52	4.34	4.34
455.56	3.87	3.87