Basic Information
ID: ALA5053314
Type: Binding
Description: Inhibition of C-terminal His6-tagged recombinant human USP19 using iso-peptide ubiquitin-Lys-TAMRA as substrate incubated for 30 mins and measured after 90 mins by fluorescent polarization assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5053314
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 588.65 | 4.53 | 4.53 |
| 497.68 | 3.78 | 3.78 |
| 591.79 | 4.84 | 4.84 |
| 509.67 | 5.18 | 5.18 |
| 642.80 | 4.76 | 4.76 |
| 559.73 | 6.31 | 6.31 |
| 457.59 | 4.11 | 4.11 |
| 469.60 | 4.40 | 4.40 |
| 449.53 | 3.60 | 3.60 |
| 555.72 | 5.13 | 5.13 |
| 519.69 | 4.32 | 4.32 |
| 521.66 | 3.31 | 3.31 |
| 512.65 | 3.78 | 3.78 |
| 415.58 | 3.37 | 3.37 |
| 557.69 | 3.66 | 3.66 |
| 543.71 | 4.85 | 4.85 |
| 590.81 | 4.50 | 4.50 |
| 503.50 | 4.14 | 4.14 |
| 563.78 | 5.59 | 5.59 |
| 525.73 | 4.56 | 4.56 |
| 565.66 | 4.79 | 4.79 |
| 495.66 | 4.00 | 4.00 |
| 555.72 | 4.93 | 4.93 |
| 527.67 | 4.30 | 4.30 |
| 477.53 | 4.02 | 4.02 |
| 541.64 | 4.18 | 4.18 |
| 563.78 | 5.59 | 5.59 |
| 571.72 | 3.91 | 3.91 |
| 445.56 | 3.77 | 3.77 |
| 526.68 | 3.83 | 3.83 |
| 563.74 | 4.07 | 4.07 |
| 473.56 | 4.12 | 4.12 |
| 421.50 | 3.05 | 3.05 |
| 515.70 | 3.69 | 3.69 |
| 495.66 | 4.00 | 4.00 |
| 465.64 | 4.51 | 4.51 |
| 590.81 | 4.55 | 4.55 |
| 471.67 | 4.57 | 4.57 |
| 471.57 | 2.84 | 2.84 |
| 528.74 | 3.75 | 3.75 |
| 469.60 | 4.40 | 4.40 |
| 591.79 | 4.84 | 4.84 |
| 467.55 | 2.57 | 2.57 |
| 525.67 | 4.17 | 4.17 |
| 503.60 | 3.50 | 3.50 |
| 487.64 | 4.12 | 4.12 |
| 535.73 | 4.81 | 4.81 |
| 561.77 | 5.35 | 5.35 |
| 453.49 | 3.17 | 3.17 |
| 592.74 | 4.90 | 4.90 |
| 527.43 | 4.65 | 4.65 |
| 507.68 | 4.03 | 4.03 |
| 590.81 | 4.81 | 4.81 |
| 555.72 | 4.93 | 4.93 |
| 503.64 | 3.54 | 3.54 |
| 573.66 | 4.72 | 4.72 |
| 576.78 | 4.16 | 4.16 |
| 495.52 | 4.16 | 4.16 |
| 574.77 | 3.91 | 3.91 |
| 529.68 | 4.54 | 4.54 |
| 599.73 | 4.04 | 4.04 |
| 655.68 | 6.19 | 6.19 |
| 426.56 | 2.86 | 2.86 |
| 563.74 | 4.48 | 4.48 |
| 458.56 | 3.88 | 3.88 |
| 615.62 | 5.26 | 5.26 |
| 496.61 | 5.32 | 5.32 |
| 543.66 | 3.54 | 3.54 |
| 507.63 | 5.12 | 5.12 |
| 501.63 | 3.76 | 3.76 |
| 540.75 | 3.37 | 3.37 |
| 547.62 | 4.33 | 4.33 |
| 510.64 | 4.46 | 4.46 |
| 588.65 | 4.53 | 4.53 |
| 470.61 | 5.10 | 5.10 |
| 538.66 | 2.88 | 2.88 |
| 616.85 | 5.03 | 5.03 |
| 561.77 | 5.35 | 5.35 |
| 494.68 | 3.97 | 3.97 |
| 488.59 | 3.42 | 3.42 |
| 547.74 | 5.10 | 5.10 |
| 507.61 | 4.12 | 4.12 |
| 427.52 | 3.37 | 3.37 |
| 591.79 | 4.84 | 4.84 |
| 541.69 | 4.69 | 4.69 |
| 469.48 | 3.63 | 3.63 |
| 461.56 | 3.47 | 3.47 |
| 519.69 | 4.18 | 4.18 |
| 575.79 | 5.74 | 5.74 |
| 577.73 | 5.33 | 5.33 |
| 535.69 | 5.19 | 5.19 |
| 588.67 | 3.67 | 3.67 |
| 543.66 | 4.42 | 4.42 |
| 509.65 | 3.17 | 3.17 |
| 535.69 | 5.19 | 5.19 |
| 531.70 | 4.32 | 4.32 |
| 495.66 | 4.00 | 4.00 |
| 464.99 | 4.72 | 4.72 |
| 533.69 | 4.14 | 4.14 |
| 523.67 | 3.01 | 3.01 |
| 461.56 | 2.95 | 2.95 |
| 481.60 | 4.61 | 4.61 |
| 554.69 | 4.41 | 4.41 |
| 562.76 | 3.86 | 3.86 |
| 561.77 | 5.35 | 5.35 |
| 445.56 | 3.70 | 3.70 |
| 511.64 | 4.07 | 4.07 |
| 453.49 | 2.98 | 2.98 |
| 503.64 | 3.54 | 3.54 |
| 494.68 | 3.97 | 3.97 |
| 618.82 | 4.42 | 4.42 |
| 527.67 | 4.20 | 4.20 |
| 523.67 | 3.01 | 3.01 |
| 579.70 | 4.44 | 4.44 |
| 573.71 | 4.68 | 4.68 |
| 547.62 | 4.33 | 4.33 |
| 447.51 | 3.21 | 3.21 |
| 547.67 | 4.68 | 4.68 |
| 511.68 | 5.28 | 5.28 |
| 602.82 | 4.69 | 4.69 |
| 543.71 | 4.85 | 4.85 |
| 483.63 | 4.65 | 4.65 |
| 517.63 | 3.70 | 3.70 |
| 557.69 | 3.34 | 3.34 |
| 512.65 | 3.44 | 3.44 |
| 559.71 | 4.55 | 4.55 |
| 565.76 | 4.18 | 4.18 |
| 602.70 | 4.02 | 4.02 |
| 531.70 | 5.77 | 5.77 |
| 427.52 | 3.23 | 3.23 |
| 620.81 | 4.83 | 4.83 |
| 495.52 | 4.16 | 4.16 |
| 559.68 | 4.51 | 4.51 |
| 493.65 | 3.79 | 3.79 |
| 481.64 | 3.79 | 3.79 |
| 520.11 | 4.33 | 4.33 |
| 517.63 | 2.78 | 2.78 |
| 477.61 | 3.15 | 3.15 |
| 551.73 | 3.79 | 3.79 |
| 553.72 | 4.95 | 4.95 |
| 552.68 | 4.54 | 4.54 |
| 521.70 | 4.42 | 4.42 |
| 507.63 | 5.12 | 5.12 |
| 541.69 | 4.69 | 4.69 |
| 589.66 | 4.10 | 4.10 |
| 485.67 | 3.68 | 3.68 |
| 459.59 | 4.09 | 4.09 |
| 521.70 | 4.57 | 4.57 |
| 509.44 | 4.83 | 4.83 |
| 467.61 | 3.30 | 3.30 |
| 473.62 | 4.13 | 4.13 |
| 566.79 | 3.90 | 3.90 |
| 533.71 | 4.71 | 4.71 |
| 467.59 | 4.01 | 4.01 |
| 469.63 | 3.24 | 3.24 |
| 538.73 | 3.12 | 3.12 |
| 469.60 | 4.40 | 4.40 |
| 593.78 | 5.88 | 5.88 |
| 602.82 | 4.69 | 4.69 |
| 455.60 | 3.23 | 3.23 |
| 606.66 | 3.81 | 3.81 |
| 513.41 | 4.40 | 4.40 |
| 591.70 | 5.18 | 5.18 |
| 495.64 | 4.79 | 4.79 |
| 467.61 | 3.64 | 3.64 |
| 561.77 | 5.35 | 5.35 |
| 455.60 | 3.23 | 3.23 |
| 523.65 | 3.88 | 3.88 |
| 579.76 | 5.49 | 5.49 |
| 427.52 | 3.23 | 3.23 |
| 430.55 | 4.06 | 4.06 |
| 481.61 | 4.57 | 4.57 |
| 563.70 | 5.34 | 5.34 |
| 395.50 | 2.82 | 2.82 |
| 519.69 | 4.32 | 4.32 |
| 493.65 | 3.64 | 3.64 |
| 485.59 | 3.34 | 3.34 |
| 534.70 | 5.34 | 5.34 |
| 513.64 | 4.19 | 4.19 |
| 509.69 | 4.57 | 4.57 |
| 605.65 | 3.07 | 3.07 |
| 565.61 | 4.47 | 4.47 |
| 535.73 | 4.81 | 4.81 |
| 459.59 | 4.24 | 4.24 |
| 563.62 | 3.30 | 3.30 |
| 457.55 | 2.73 | 2.73 |
| 445.56 | 4.02 | 4.02 |
| 559.73 | 5.74 | 5.74 |
| 535.69 | 3.56 | 3.56 |
| 507.63 | 5.12 | 5.12 |
| 499.70 | 4.02 | 4.02 |
| 531.66 | 5.60 | 5.60 |
| 551.73 | 3.79 | 3.79 |
| 455.57 | 4.01 | 4.01 |
| 515.53 | 4.36 | 4.36 |
| 541.64 | 4.18 | 4.18 |
| 553.70 | 4.54 | 4.54 |
| 559.63 | 4.33 | 4.33 |
| 491.40 | 4.35 | 4.35 |
| 562.75 | 5.82 | 5.82 |
| 567.80 | 5.41 | 5.41 |
| 510.64 | 4.46 | 4.46 |
| 441.55 | 3.76 | 3.76 |
| 455.56 | 3.93 | 3.93 |
| 542.68 | 3.11 | 3.11 |
| 455.57 | 4.01 | 4.01 |
| 479.62 | 3.40 | 3.40 |
| 506.65 | 5.73 | 5.73 |
| 576.78 | 4.16 | 4.16 |
| 508.66 | 4.81 | 4.81 |
| 449.56 | 2.50 | 2.50 |
| 503.60 | 2.78 | 2.78 |
| 475.56 | 3.84 | 3.84 |
| 437.57 | 3.52 | 3.52 |
| 431.54 | 3.53 | 3.53 |
| 563.70 | 5.69 | 5.69 |
| 592.76 | 4.05 | 4.05 |
| 431.54 | 3.21 | 3.21 |
| 604.67 | 2.65 | 2.65 |
| 616.85 | 5.08 | 5.08 |
| 497.66 | 5.04 | 5.04 |
| 549.67 | 4.83 | 4.83 |
| 591.70 | 5.18 | 5.18 |
| 491.61 | 4.41 | 4.41 |
| 521.58 | 3.80 | 3.80 |
| 553.66 | 3.93 | 3.93 |
| 494.68 | 3.97 | 3.97 |
| 521.70 | 4.71 | 4.71 |
| 606.81 | 3.52 | 3.52 |
| 533.59 | 4.08 | 4.08 |
| 551.70 | 4.71 | 4.71 |
| 508.62 | 4.52 | 4.52 |
| 465.64 | 4.82 | 4.82 |
| 533.71 | 4.57 | 4.57 |
| 535.73 | 4.96 | 4.96 |
| 435.57 | 3.75 | 3.75 |
| 439.53 | 3.54 | 3.54 |
| 463.55 | 3.67 | 3.67 |
| 565.76 | 4.18 | 4.18 |
| 529.63 | 4.03 | 4.03 |
| 549.71 | 4.09 | 4.09 |
| 577.77 | 4.58 | 4.58 |
| 641.85 | 6.01 | 6.01 |
| 444.58 | 4.37 | 4.37 |
| 589.58 | 4.73 | 4.73 |
| 544.65 | 3.92 | 3.92 |
| 502.61 | 4.24 | 4.24 |
| 441.55 | 3.62 | 3.62 |
| 609.78 | 4.85 | 4.85 |
| 505.43 | 4.74 | 4.74 |
| 431.54 | 3.46 | 3.46 |
| 455.57 | 3.87 | 3.87 |
| 475.56 | 3.53 | 3.53 |
| 465.53 | 3.72 | 3.72 |
| 577.77 | 4.58 | 4.58 |
| 529.68 | 4.54 | 4.54 |
| 580.69 | 4.71 | 4.71 |
| 603.80 | 5.12 | 5.12 |
| 565.76 | 4.44 | 4.44 |
| 475.56 | 3.84 | 3.84 |