Basic Information
ID: ALA5053341
Type: Binding
Description: Inhibition of C-terminal His6-tagged recombinant human USP19 using iso-peptide ubiquitin-Lys-TAMRA as substrate incubated for 30 mins and measured after 90 mins by fluorescent polarization assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5053341
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 531.66 | 2.41 | 2.41 |
| 439.48 | 3.15 | 3.15 |
| 528.65 | 4.10 | 4.10 |
| 581.64 | 4.09 | 4.09 |
| 544.67 | 4.42 | 4.42 |
| 490.65 | 3.49 | 3.49 |
| 485.93 | 4.16 | 4.16 |
| 440.58 | 3.88 | 3.88 |
| 481.52 | 2.95 | 2.95 |
| 517.63 | 3.29 | 3.29 |
| 464.49 | 3.18 | 3.18 |
| 544.67 | 4.42 | 4.42 |
| 530.67 | 3.01 | 3.01 |
| 482.50 | 2.91 | 2.91 |
| 452.52 | 4.07 | 4.07 |
| 544.65 | 3.34 | 3.34 |
| 513.64 | 4.15 | 4.15 |
| 500.64 | 3.74 | 3.74 |
| 464.57 | 2.50 | 2.50 |
| 511.63 | 3.88 | 3.88 |
| 454.61 | 4.72 | 4.72 |
| 480.69 | 5.13 | 5.13 |
| 537.61 | 3.44 | 3.44 |
| 557.70 | 3.68 | 3.68 |
| 563.65 | 3.95 | 3.95 |
| 469.51 | 2.73 | 2.73 |
| 563.72 | 3.74 | 3.74 |
| 525.69 | 4.54 | 4.54 |
| 476.62 | 3.90 | 3.90 |
| 574.63 | 4.32 | 4.32 |
| 440.63 | 4.04 | 4.04 |
| 495.62 | 1.95 | 1.95 |
| 519.62 | 3.30 | 3.30 |
| 502.62 | 3.57 | 3.57 |
| 486.66 | 3.08 | 3.08 |
| 479.67 | 4.84 | 4.84 |
| 502.62 | 3.59 | 3.59 |
| 552.70 | 2.95 | 2.95 |
| 503.61 | 2.98 | 2.98 |
| 503.92 | 4.30 | 4.30 |
| 545.68 | 4.98 | 4.98 |
| 532.49 | 4.11 | 4.11 |
| 454.62 | 3.85 | 3.85 |
| 482.60 | 3.71 | 3.71 |
| 541.70 | 3.85 | 3.85 |
| 501.63 | 3.78 | 3.78 |
| 476.58 | 2.55 | 2.55 |
| 508.57 | 4.10 | 4.10 |
| 581.64 | 4.09 | 4.09 |
| 471.67 | 4.59 | 4.59 |
| 420.47 | 2.35 | 2.35 |
| 534.68 | 4.16 | 4.16 |
| 552.78 | 5.38 | 5.38 |
| 493.65 | 2.96 | 2.96 |
| 469.63 | 3.94 | 3.94 |
| 509.57 | 3.08 | 3.08 |
| 507.64 | 2.58 | 2.58 |
| 480.53 | 4.12 | 4.12 |
| 469.63 | 3.26 | 3.26 |
| 480.65 | 4.23 | 4.23 |
| 550.64 | 2.97 | 2.97 |
| 466.63 | 3.90 | 3.90 |
| 581.72 | 3.41 | 3.41 |
| 455.60 | 3.03 | 3.03 |
| 573.77 | 5.61 | 5.61 |
| 519.69 | 3.21 | 3.21 |
| 532.71 | 4.80 | 4.80 |
| 577.68 | 4.26 | 4.26 |
| 442.56 | 1.58 | 1.58 |
| 581.64 | 4.09 | 4.09 |
| 540.17 | 4.99 | 4.99 |
| 446.51 | 2.74 | 2.74 |
| 593.68 | 3.96 | 3.96 |
| 541.70 | 4.19 | 4.19 |
| 563.65 | 3.95 | 3.95 |
| 478.62 | 3.88 | 3.88 |
| 532.69 | 2.46 | 2.46 |
| 479.67 | 4.84 | 4.84 |
| 430.94 | 2.80 | 2.80 |
| 457.52 | 3.57 | 3.57 |
| 562.66 | 4.56 | 4.56 |
| 428.58 | 3.09 | 3.09 |
| 465.60 | 2.32 | 2.32 |
| 466.63 | 3.92 | 3.92 |
| 478.59 | 2.89 | 2.89 |
| 599.66 | 3.43 | 3.43 |
| 505.66 | 4.18 | 4.18 |
| 528.66 | 3.07 | 3.07 |
| 562.66 | 4.56 | 4.56 |
| 495.62 | 2.50 | 2.50 |
| 537.58 | 2.74 | 2.74 |
| 466.63 | 3.90 | 3.90 |
| 531.66 | 2.41 | 2.41 |
| 509.65 | 4.01 | 4.01 |
| 557.70 | 3.68 | 3.68 |
| 535.73 | 4.83 | 4.83 |
| 511.13 | 4.37 | 4.37 |
| 478.59 | 2.96 | 2.96 |
| 581.82 | 6.00 | 6.00 |
| 533.70 | 3.74 | 3.74 |
| 476.58 | 3.75 | 3.75 |
| 465.64 | 4.51 | 4.51 |
| 550.63 | 2.66 | 2.66 |
| 466.63 | 3.92 | 3.92 |
| 487.00 | 3.09 | 3.09 |
| 567.67 | 4.99 | 4.99 |
| 453.63 | 4.17 | 4.17 |
| 580.70 | 5.10 | 5.10 |
| 527.62 | 3.16 | 3.16 |
| 516.60 | 3.55 | 3.55 |
| 542.68 | 4.49 | 4.49 |
| 539.60 | 5.53 | 5.53 |
| 473.58 | 3.21 | 3.21 |
| 543.61 | 3.26 | 3.26 |
| 434.62 | 2.96 | 2.96 |
| 562.76 | 4.85 | 4.85 |
| 504.99 | 3.23 | 3.23 |
| 505.62 | 1.89 | 1.89 |
| 577.68 | 4.61 | 4.61 |
| 415.58 | 3.37 | 3.37 |
| 568.67 | 2.74 | 2.74 |
| 426.60 | 4.24 | 4.24 |
| 504.63 | 2.88 | 2.88 |
| 575.74 | 4.13 | 4.13 |
| 563.65 | 3.95 | 3.95 |
| 483.66 | 3.74 | 3.74 |
| 486.56 | 3.61 | 3.61 |
| 545.66 | 3.81 | 3.81 |
| 448.57 | 2.98 | 2.98 |
| 465.64 | 4.53 | 4.53 |
| 472.59 | 3.82 | 3.82 |
| 480.61 | 2.05 | 2.05 |
| 448.53 | 2.98 | 2.98 |
| 575.69 | 3.82 | 3.82 |
| 545.66 | 3.81 | 3.81 |
| 482.64 | 5.27 | 5.27 |
| 461.65 | 2.81 | 2.81 |
| 473.58 | 3.21 | 3.21 |
| 511.63 | 4.03 | 4.03 |
| 450.51 | 3.13 | 3.13 |
| 466.63 | 3.92 | 3.92 |
| 457.57 | 2.04 | 2.04 |
| 550.64 | 2.97 | 2.97 |
| 612.70 | 3.78 | 3.78 |
| 453.63 | 4.17 | 4.17 |
| 462.55 | 3.41 | 3.41 |
| 546.64 | 4.24 | 4.24 |
| 483.63 | 4.67 | 4.67 |
| 568.68 | 3.98 | 3.98 |
| 563.65 | 3.95 | 3.95 |
| 582.71 | 3.83 | 3.83 |
| 588.77 | 4.02 | 4.02 |
| 502.62 | 2.56 | 2.56 |
| 542.68 | 4.12 | 4.12 |
| 496.61 | 2.37 | 2.37 |
| 483.65 | 4.12 | 4.12 |
| 527.71 | 2.42 | 2.42 |
| 518.07 | 5.32 | 5.32 |
| 501.63 | 4.17 | 4.17 |
| 569.71 | 3.61 | 3.61 |
| 513.71 | 4.04 | 4.04 |
| 517.55 | 3.69 | 3.69 |
| 545.66 | 3.81 | 3.81 |
| 481.60 | 1.99 | 1.99 |
| 575.69 | 3.82 | 3.82 |
| 495.55 | 2.97 | 2.97 |
| 471.60 | 4.42 | 4.42 |
| 520.61 | 3.73 | 3.73 |
| 570.69 | 3.24 | 3.24 |
| 595.67 | 4.69 | 4.69 |
| 514.63 | 3.85 | 3.85 |
| 506.65 | 3.53 | 3.53 |
| 501.63 | 3.14 | 3.14 |
| 495.13 | 5.35 | 5.35 |
| 469.48 | 3.65 | 3.65 |
| 501.62 | 4.81 | 4.81 |
| 491.64 | 2.88 | 2.88 |
| 541.76 | 5.15 | 5.15 |
| 557.70 | 3.68 | 3.68 |
| 531.70 | 4.71 | 4.71 |
| 492.62 | 1.99 | 1.99 |
| 472.63 | 2.97 | 2.97 |
| 536.60 | 2.31 | 2.31 |
| 495.71 | 4.47 | 4.47 |
| 557.70 | 3.68 | 3.68 |
| 481.52 | 3.52 | 3.52 |
| 420.47 | 2.35 | 2.35 |
| 520.68 | 2.61 | 2.61 |
| 541.70 | 4.19 | 4.19 |
| 432.53 | 3.75 | 3.75 |
| 473.58 | 3.21 | 3.21 |
| 526.68 | 4.28 | 4.28 |
| 497.60 | 3.69 | 3.69 |
| 466.63 | 3.90 | 3.90 |
| 595.67 | 4.69 | 4.69 |
| 526.14 | 4.67 | 4.67 |
| 461.61 | 3.10 | 3.10 |
| 466.62 | 4.35 | 4.35 |
| 576.72 | 3.50 | 3.50 |
| 583.73 | 4.22 | 4.22 |
| 569.71 | 3.93 | 3.93 |
| 462.53 | 3.18 | 3.18 |
| 551.61 | 2.05 | 2.05 |
| 454.55 | 3.12 | 3.12 |
| 509.63 | 3.02 | 3.02 |
| 451.57 | 2.01 | 2.01 |
| 485.93 | 4.16 | 4.16 |
| 439.48 | 3.15 | 3.15 |
| 429.61 | 3.72 | 3.72 |
| 567.80 | 5.68 | 5.68 |
| 459.61 | 3.43 | 3.43 |
| 538.60 | 3.87 | 3.87 |
| 504.59 | 3.08 | 3.08 |
| 501.58 | 2.96 | 2.96 |
| 572.71 | 3.87 | 3.87 |
| 510.72 | 4.01 | 4.01 |
| 447.50 | 1.79 | 1.79 |
| 528.65 | 4.10 | 4.10 |
| 465.60 | 2.32 | 2.32 |
| 541.70 | 4.02 | 4.02 |
| 568.78 | 5.05 | 5.05 |
| 505.66 | 4.18 | 4.18 |
| 527.13 | 4.04 | 4.04 |
| 499.56 | 3.02 | 3.02 |
| 505.62 | 1.89 | 1.89 |
| 480.61 | 2.90 | 2.90 |
| 533.70 | 3.74 | 3.74 |
| 536.78 | 6.37 | 6.37 |
| 454.66 | 4.43 | 4.43 |
| 563.65 | 3.95 | 3.95 |
| 450.58 | 3.51 | 3.51 |
| 387.52 | 2.59 | 2.59 |
| 483.66 | 3.74 | 3.74 |
| 521.66 | 3.03 | 3.03 |
| 471.67 | 4.59 | 4.59 |
| 541.65 | 3.20 | 3.20 |
| 494.68 | 5.14 | 5.14 |
| 519.73 | 4.20 | 4.20 |
| 494.72 | 5.21 | 5.21 |
| 490.53 | 3.52 | 3.52 |
| 455.60 | 3.23 | 3.23 |
| 465.60 | 2.32 | 2.32 |
| 450.02 | 4.03 | 4.03 |
| 527.67 | 3.67 | 3.67 |
| 531.58 | 3.75 | 3.75 |
| 518.50 | 5.13 | 5.13 |
| 462.59 | 3.37 | 3.37 |
| 389.54 | 2.84 | 2.84 |
| 451.49 | 3.51 | 3.51 |
| 570.69 | 3.24 | 3.24 |
| 538.57 | 2.14 | 2.14 |
| 476.62 | 3.76 | 3.76 |
| 464.54 | 3.42 | 3.42 |
| 492.62 | 3.31 | 3.31 |
| 468.57 | 3.51 | 3.51 |
| 534.71 | 3.00 | 3.00 |
| 473.61 | 3.16 | 3.16 |
| 545.66 | 3.81 | 3.81 |
| 555.76 | 3.28 | 3.28 |
| 476.58 | 3.97 | 3.97 |
| 555.76 | 3.28 | 3.28 |
| 504.55 | 4.05 | 4.05 |
| 559.69 | 4.12 | 4.12 |
| 452.48 | 2.90 | 2.90 |
| 540.59 | 4.92 | 4.92 |
| 500.08 | 5.18 | 5.18 |
| 482.55 | 2.84 | 2.84 |
| 530.67 | 3.01 | 3.01 |
| 541.70 | 3.98 | 3.98 |
| 470.68 | 5.19 | 5.19 |
| 563.65 | 3.95 | 3.95 |
| 513.64 | 3.28 | 3.28 |
| 501.63 | 3.16 | 3.16 |
| 492.66 | 4.44 | 4.44 |
| 464.61 | 3.76 | 3.76 |
| 508.57 | 4.10 | 4.10 |
| 468.68 | 4.67 | 4.67 |
| 494.68 | 5.14 | 5.14 |
| 569.71 | 3.61 | 3.61 |
| 514.63 | 3.71 | 3.71 |
| 454.66 | 4.60 | 4.60 |
| 488.54 | 2.95 | 2.95 |
| 527.67 | 3.67 | 3.67 |
| 532.65 | 2.83 | 2.83 |
| 570.74 | 3.74 | 3.74 |
| 548.71 | 3.28 | 3.28 |
| 476.58 | 2.55 | 2.55 |
| 528.65 | 4.10 | 4.10 |
| 446.55 | 3.99 | 3.99 |
| 433.64 | 2.89 | 2.89 |
| 469.63 | 3.26 | 3.26 |
| 575.69 | 3.82 | 3.82 |
| 495.71 | 5.34 | 5.34 |
| 497.70 | 2.22 | 2.22 |
| 574.64 | 4.22 | 4.22 |
| 490.58 | 3.96 | 3.96 |
| 541.70 | 3.98 | 3.98 |
| 563.65 | 3.95 | 3.95 |
| 515.72 | 3.98 | 3.98 |
| 452.56 | 2.43 | 2.43 |
| 503.60 | 3.85 | 3.85 |
| 544.72 | 4.82 | 4.82 |
| 403.57 | 3.15 | 3.15 |
| 609.69 | 4.95 | 4.95 |
| 581.82 | 6.00 | 6.00 |
| 572.77 | 5.00 | 5.00 |
| 563.65 | 3.95 | 3.95 |
| 543.67 | 2.91 | 2.91 |
| 481.52 | 3.04 | 3.04 |
| 593.67 | 4.28 | 4.28 |
| 513.64 | 4.26 | 4.26 |
| 604.77 | 3.68 | 3.68 |
| 455.48 | 2.24 | 2.24 |
| 446.68 | 4.77 | 4.77 |
| 454.66 | 4.60 | 4.60 |
| 494.47 | 4.14 | 4.14 |
| 512.65 | 4.86 | 4.86 |
| 545.66 | 3.81 | 3.81 |
| 533.70 | 3.74 | 3.74 |
| 468.49 | 4.25 | 4.25 |
| 474.56 | 2.93 | 2.93 |
| 541.70 | 4.06 | 4.06 |
| 557.70 | 3.68 | 3.68 |
| 500.08 | 5.18 | 5.18 |
| 562.11 | 4.33 | 4.33 |
| 524.70 | 5.15 | 5.15 |
| 611.66 | 4.57 | 4.57 |
| 583.73 | 4.22 | 4.22 |
| 473.58 | 3.21 | 3.21 |
| 533.70 | 3.74 | 3.74 |
| 420.59 | 2.98 | 2.98 |
| 483.63 | 4.67 | 4.67 |
| 492.62 | 3.14 | 3.14 |
| 497.60 | 3.69 | 3.69 |
| 541.70 | 3.98 | 3.98 |
| 465.60 | 2.32 | 2.32 |
| 498.57 | 3.63 | 3.63 |
| 520.55 | 3.29 | 3.29 |
| 573.77 | 5.61 | 5.61 |
| 465.60 | 2.75 | 2.75 |
| 506.65 | 3.53 | 3.53 |
| 505.62 | 1.89 | 1.89 |
| 548.73 | 4.60 | 4.60 |
| 493.63 | 3.62 | 3.62 |
| 604.77 | 4.74 | 4.74 |
| 553.74 | 4.60 | 4.60 |
| 469.48 | 3.65 | 3.65 |
| 603.79 | 4.31 | 4.31 |
| 473.58 | 2.50 | 2.50 |
| 452.64 | 4.77 | 4.77 |
| 500.59 | 4.00 | 4.00 |
| 531.66 | 2.41 | 2.41 |
| 500.11 | 4.13 | 4.13 |
| 521.58 | 3.82 | 3.82 |
| 556.66 | 2.85 | 2.85 |
| 545.66 | 3.81 | 3.81 |
| 611.71 | 4.41 | 4.41 |
| 520.67 | 4.06 | 4.06 |
| 450.58 | 3.51 | 3.51 |
| 468.68 | 4.67 | 4.67 |
| 505.66 | 3.10 | 3.10 |
| 542.63 | 2.46 | 2.46 |
| 492.66 | 4.44 | 4.44 |
| 485.03 | 3.27 | 3.27 |
| 512.72 | 4.64 | 4.64 |
| 481.60 | 2.02 | 2.02 |
| 490.58 | 3.96 | 3.96 |
| 419.61 | 2.55 | 2.55 |
| 464.61 | 3.90 | 3.90 |
| 481.56 | 3.45 | 3.45 |
| 510.55 | 4.13 | 4.13 |
| 513.64 | 4.26 | 4.26 |
| 476.62 | 3.90 | 3.90 |
| 508.57 | 4.10 | 4.10 |
| 456.59 | 1.61 | 1.61 |
| 406.45 | 1.96 | 1.96 |
| 459.59 | 3.07 | 3.07 |
| 487.60 | 3.55 | 3.55 |
| 504.55 | 3.91 | 3.91 |
| 567.69 | 3.35 | 3.35 |
| 532.65 | 2.83 | 2.83 |
| 486.56 | 3.66 | 3.66 |
| 465.64 | 4.53 | 4.53 |
| 575.69 | 3.82 | 3.82 |
| 432.48 | 2.49 | 2.49 |
| 531.66 | 2.69 | 2.69 |
| 450.58 | 3.37 | 3.37 |
| 491.64 | 2.71 | 2.71 |
| 569.71 | 3.70 | 3.70 |
| 508.57 | 4.10 | 4.10 |
| 450.58 | 3.42 | 3.42 |
| 556.71 | 4.47 | 4.47 |
| 515.66 | 4.21 | 4.21 |
| 476.58 | 3.75 | 3.75 |
| 401.43 | 2.36 | 2.36 |
| 618.80 | 5.07 | 5.07 |
| 557.70 | 3.68 | 3.68 |