Basic Information
ID: ALA5053357
Type: Binding
Description: Inhibition of recombinant His-tagged human KIF18A (1 to 467 residues) expressed in baculovirus expression system assessed as inhibition of microtubule-stimulated ATPase activity preincubated for 15 mins followed by ATP addition and further incubated for 15 mins and measured after 40 mins by ADP-Glo reagent based assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5053357
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 468.62 | 4.20 | 4.20 |
| 540.69 | 3.60 | 3.60 |
| 524.69 | 4.63 | 4.63 |
| 513.66 | 3.34 | 3.34 |
| 535.69 | 3.16 | 3.16 |
| 547.73 | 5.40 | 5.40 |
| 526.70 | 4.61 | 4.61 |
| 581.66 | 3.90 | 3.90 |
| 425.55 | 4.04 | 4.04 |
| 543.73 | 4.28 | 4.28 |
| 545.71 | 2.95 | 2.95 |
| 475.59 | 4.86 | 4.86 |
| 595.77 | 5.23 | 5.23 |
| 539.70 | 3.77 | 3.77 |
| 540.73 | 5.00 | 5.00 |
| 510.66 | 3.61 | 3.61 |
| 453.61 | 4.82 | 4.82 |
| 512.68 | 4.22 | 4.22 |
| 595.77 | 5.23 | 5.23 |
| 556.73 | 3.89 | 3.89 |
| 525.02 | 4.79 | 4.79 |
| 441.60 | 4.68 | 4.68 |
| 524.69 | 4.37 | 4.37 |
| 534.70 | 3.34 | 3.34 |
| 559.73 | 3.98 | 3.98 |
| 513.66 | 3.60 | 3.60 |
| 511.64 | 4.21 | 4.21 |
| 524.69 | 4.63 | 4.63 |
| 543.69 | 2.70 | 2.70 |
| 569.47 | 4.90 | 4.90 |
| 453.61 | 4.82 | 4.82 |
| 547.70 | 4.11 | 4.11 |
| 454.60 | 3.89 | 3.89 |
| 543.69 | 2.96 | 2.96 |
| 541.72 | 4.12 | 4.12 |
| 455.62 | 5.07 | 5.07 |
| 525.72 | 4.40 | 4.40 |
| 526.70 | 4.61 | 4.61 |
| 511.65 | 3.09 | 3.09 |
| 547.67 | 4.64 | 4.64 |
| 538.71 | 4.68 | 4.68 |
| 527.69 | 3.73 | 3.73 |
| 529.66 | 2.31 | 2.31 |
| 522.68 | 3.75 | 3.75 |
| 485.63 | 5.27 | 5.27 |
| 541.72 | 4.12 | 4.12 |
| 508.69 | 5.03 | 5.03 |
| 526.58 | 4.19 | 4.19 |
| 508.57 | 4.27 | 4.27 |
| 504.60 | 4.52 | 4.52 |
| 499.66 | 5.58 | 5.58 |
| 539.70 | 3.87 | 3.87 |
| 510.70 | 5.64 | 5.64 |
| 462.52 | 3.35 | 3.35 |
| 511.64 | 4.26 | 4.26 |
| 553.61 | 3.84 | 3.84 |
| 559.73 | 3.98 | 3.98 |
| 564.15 | 4.63 | 4.63 |
| 468.62 | 4.33 | 4.33 |
| 524.69 | 4.37 | 4.37 |
| 428.56 | 3.40 | 3.40 |
| 476.55 | 3.74 | 3.74 |
| 480.57 | 4.65 | 4.65 |
| 569.65 | 4.47 | 4.47 |
| 454.60 | 3.94 | 3.94 |
| 470.64 | 4.53 | 4.53 |
| 524.69 | 4.37 | 4.37 |
| 608.60 | 4.74 | 4.74 |
| 527.69 | 3.36 | 3.36 |
| 442.59 | 3.79 | 3.79 |
| 511.64 | 4.26 | 4.26 |
| 440.57 | 3.55 | 3.55 |
| 524.69 | 3.86 | 3.86 |
| 575.76 | 3.02 | 3.02 |
| 538.71 | 4.76 | 4.76 |
| 527.69 | 3.63 | 3.63 |
| 554.76 | 5.31 | 5.31 |
| 538.71 | 4.66 | 4.66 |
| 476.55 | 3.79 | 3.79 |
| 514.69 | 4.33 | 4.33 |
| 512.68 | 4.22 | 4.22 |
| 566.65 | 5.11 | 5.11 |
| 475.59 | 4.86 | 4.86 |
| 474.61 | 5.47 | 5.47 |
| 569.77 | 4.85 | 4.85 |
| 543.69 | 2.96 | 2.96 |
| 538.71 | 4.76 | 4.76 |
| 426.54 | 3.16 | 3.16 |
| 440.57 | 3.46 | 3.46 |
| 515.68 | 3.59 | 3.59 |
| 554.76 | 5.39 | 5.39 |
| 486.61 | 4.23 | 4.23 |
| 454.60 | 3.89 | 3.89 |
| 476.58 | 4.26 | 4.26 |
| 606.79 | 5.04 | 5.04 |
| 527.69 | 3.99 | 3.99 |
| 497.67 | 4.00 | 4.00 |
| 547.67 | 5.00 | 5.00 |
| 491.64 | 4.33 | 4.33 |
| 474.61 | 4.30 | 4.30 |
| 468.62 | 4.28 | 4.28 |
| 455.62 | 5.07 | 5.07 |
| 425.55 | 3.90 | 3.90 |
| 439.58 | 4.43 | 4.43 |
| 517.65 | 2.86 | 2.86 |
| 541.72 | 4.12 | 4.12 |
| 541.72 | 4.12 | 4.12 |
| 512.68 | 4.22 | 4.22 |
| 485.63 | 5.27 | 5.27 |
| 470.64 | 4.44 | 4.44 |
| 474.61 | 4.60 | 4.60 |
| 531.68 | 2.56 | 2.56 |
| 439.58 | 4.43 | 4.43 |
| 479.63 | 3.73 | 3.73 |
| 453.61 | 4.74 | 4.74 |
| 512.68 | 4.49 | 4.49 |
| 456.61 | 4.13 | 4.13 |
| 514.69 | 4.47 | 4.47 |
| 490.58 | 4.13 | 4.13 |
| 512.68 | 4.22 | 4.22 |
| 527.69 | 3.99 | 3.99 |
| 539.75 | 5.03 | 5.03 |
| 474.61 | 4.30 | 4.30 |
| 528.68 | 3.20 | 3.20 |
| 457.57 | 4.57 | 4.57 |
| 510.66 | 4.24 | 4.24 |
| 541.72 | 4.12 | 4.12 |
| 543.73 | 4.36 | 4.36 |
| 538.71 | 4.76 | 4.76 |
| 512.68 | 4.22 | 4.22 |
| 553.73 | 4.51 | 4.51 |
| 472.59 | 3.84 | 3.84 |
| 456.61 | 4.13 | 4.13 |
| 568.66 | 5.01 | 5.01 |
| 485.63 | 5.27 | 5.27 |
| 469.61 | 4.44 | 4.44 |
| 526.70 | 4.61 | 4.61 |
| 493.65 | 4.43 | 4.43 |
| 491.66 | 5.33 | 5.33 |
| 490.58 | 4.13 | 4.13 |
| 527.69 | 3.73 | 3.73 |
| 523.70 | 4.25 | 4.25 |
| 475.56 | 4.68 | 4.68 |
| 540.73 | 4.92 | 4.92 |
| 489.59 | 5.07 | 5.07 |
| 504.60 | 4.44 | 4.44 |
| 529.71 | 3.97 | 3.97 |
| 527.69 | 3.36 | 3.36 |
| 440.57 | 3.55 | 3.55 |
| 493.65 | 4.04 | 4.04 |
| 512.68 | 4.22 | 4.22 |
| 539.75 | 5.17 | 5.17 |
| 547.70 | 4.11 | 4.11 |
| 527.69 | 3.63 | 3.63 |
| 557.72 | 3.35 | 3.35 |
| 442.59 | 3.79 | 3.79 |
| 527.69 | 3.13 | 3.13 |
| 474.61 | 5.47 | 5.47 |
| 496.68 | 5.25 | 5.25 |
| 512.68 | 4.22 | 4.22 |
| 490.58 | 4.13 | 4.13 |
| 523.70 | 4.39 | 4.39 |
| 541.72 | 4.12 | 4.12 |
| 463.63 | 4.50 | 4.50 |
| 542.70 | 3.59 | 3.59 |
| 543.73 | 4.28 | 4.28 |
| 547.70 | 4.11 | 4.11 |
| 475.59 | 4.86 | 4.86 |
| 527.69 | 3.36 | 3.36 |
| 538.71 | 4.76 | 4.76 |
| 460.58 | 3.74 | 3.74 |
| 511.69 | 4.76 | 4.76 |