ID: ALA5053383
Type: Binding
Description: Inhibition of METTL3 (unknown origin) using UCUGGACUAAA-biotin and 3H-SAM as substrates preincubated for 5 mins followed by substrate addition incubated for 30 mins by TopCount scintillation counting method
Organism: Homo sapiens
Bioactivity
Activity Types for Assay ALA5053383
IC50
Parent Molecular Weight | ALogP | Polar Surface Area |
---|---|---|
431.89 | 4.07 | 4.07 |
600.77 | 6.59 | 6.59 |
491.56 | 4.36 | 4.36 |
436.52 | 5.05 | 5.05 |
473.92 | 3.92 | 3.92 |
527.59 | 2.68 | 2.68 |
493.57 | 4.59 | 4.59 |
517.55 | 3.31 | 3.31 |
465.56 | 4.86 | 4.86 |
531.58 | 4.05 | 4.05 |
483.58 | 3.46 | 3.46 |
521.59 | 3.35 | 3.35 |
494.56 | 3.98 | 3.98 |
467.53 | 4.55 | 4.55 |
529.61 | 4.53 | 4.53 |
559.68 | 5.33 | 5.33 |
461.53 | 3.71 | 3.71 |
444.93 | 5.22 | 5.22 |
560.62 | 3.25 | 3.25 |
493.57 | 4.59 | 4.59 |
551.65 | 4.78 | 4.78 |
411.47 | 3.67 | 3.67 |
545.61 | 3.76 | 3.76 |
494.56 | 3.98 | 3.98 |
388.48 | 2.64 | 2.64 |
583.68 | 3.41 | 3.41 |
439.52 | 4.40 | 4.40 |
396.45 | 4.38 | 4.38 |
438.90 | 3.68 | 3.68 |
489.59 | 4.56 | 4.56 |
494.56 | 2.26 | 2.26 |
539.62 | 5.29 | 5.29 |
519.57 | 3.11 | 3.11 |
466.55 | 4.62 | 4.62 |
459.94 | 4.78 | 4.78 |
469.55 | 4.15 | 4.15 |
540.63 | 4.39 | 4.39 |
505.63 | 5.78 | 5.78 |
558.62 | 4.53 | 4.53 |
495.55 | 2.73 | 2.73 |
383.42 | 3.11 | 3.11 |
496.54 | 3.15 | 3.15 |
547.67 | 4.75 | 4.75 |
563.62 | 2.72 | 2.72 |
416.87 | 4.37 | 4.37 |
586.74 | 6.20 | 6.20 |
477.53 | 5.14 | 5.14 |
469.55 | 4.35 | 4.35 |
517.49 | 3.63 | 3.63 |
550.67 | 4.35 | 4.35 |
425.50 | 4.13 | 4.13 |
550.63 | 3.94 | 3.94 |
547.58 | 3.29 | 3.29 |
431.89 | 4.22 | 4.22 |
494.60 | 4.38 | 4.38 |
411.47 | 4.08 | 4.08 |
538.57 | 3.56 | 3.56 |
397.44 | 3.57 | 3.57 |
397.44 | 3.42 | 3.42 |
565.66 | 4.89 | 4.89 |
480.57 | 5.04 | 5.04 |
446.90 | 4.53 | 4.53 |
533.60 | 3.76 | 3.76 |
518.59 | 3.07 | 3.07 |
429.92 | 4.43 | 4.43 |
448.89 | 4.96 | 4.96 |
397.44 | 3.77 | 3.77 |
459.94 | 5.00 | 5.00 |
476.54 | 4.49 | 4.49 |
551.64 | 3.53 | 3.53 |
535.65 | 5.54 | 5.54 |
494.65 | 4.66 | 4.66 |
521.56 | 4.27 | 4.27 |
547.62 | 4.24 | 4.24 |
430.90 | 4.67 | 4.67 |
550.71 | 5.12 | 5.12 |
450.55 | 5.12 | 5.12 |
578.70 | 4.81 | 4.81 |
464.57 | 5.83 | 5.83 |
542.58 | 3.43 | 3.43 |
465.56 | 5.22 | 5.22 |
482.59 | 4.06 | 4.06 |
536.64 | 4.93 | 4.93 |
504.56 | 3.53 | 3.53 |
550.67 | 4.35 | 4.35 |
572.72 | 5.81 | 5.81 |
580.67 | 4.60 | 4.60 |
567.60 | 5.16 | 5.16 |
712.71 | 3.96 | 3.96 |
426.48 | 3.87 | 3.87 |
543.64 | 4.92 | 4.92 |
423.52 | 4.44 | 4.44 |
460.93 | 4.83 | 4.83 |
440.51 | 3.63 | 3.63 |
453.51 | 3.23 | 3.23 |
539.64 | 5.00 | 5.00 |
561.69 | 4.78 | 4.78 |
479.59 | 5.33 | 5.33 |
450.55 | 5.64 | 5.64 |
431.89 | 4.22 | 4.22 |
539.64 | 5.00 | 5.00 |
481.56 | 4.81 | 4.81 |
384.40 | 2.82 | 2.82 |
411.47 | 3.88 | 3.88 |
505.59 | 4.53 | 4.53 |
467.53 | 4.42 | 4.42 |
432.88 | 3.62 | 3.62 |
551.65 | 4.78 | 4.78 |
480.58 | 4.41 | 4.41 |
540.43 | 4.48 | 4.48 |
548.66 | 4.15 | 4.15 |
474.37 | 4.97 | 4.97 |
414.44 | 4.31 | 4.31 |
464.58 | 4.83 | 4.83 |
426.48 | 3.66 | 3.66 |
519.64 | 4.85 | 4.85 |
467.53 | 3.88 | 3.88 |
396.45 | 4.29 | 4.29 |
567.63 | 4.69 | 4.69 |
523.40 | 2.37 | 2.37 |
539.60 | 2.87 | 2.87 |
448.89 | 4.96 | 4.96 |
426.48 | 3.63 | 3.63 |
475.35 | 4.93 | 4.93 |
421.46 | 4.04 | 4.04 |
535.64 | 3.86 | 3.86 |
477.53 | 3.97 | 3.97 |
481.56 | 4.81 | 4.81 |
460.93 | 4.83 | 4.83 |
523.60 | 4.90 | 4.90 |
467.58 | 4.28 | 4.28 |
531.59 | 4.43 | 4.43 |
504.55 | 4.70 | 4.70 |
479.50 | 3.61 | 3.61 |
470.96 | 5.38 | 5.38 |
491.60 | 5.39 | 5.39 |
523.60 | 3.44 | 3.44 |
464.49 | 4.22 | 4.22 |
515.57 | 5.86 | 5.86 |
411.47 | 3.88 | 3.88 |
559.58 | 3.83 | 3.83 |
524.59 | 2.00 | 2.00 |
413.46 | 3.91 | 3.91 |
483.54 | 2.66 | 2.66 |
497.61 | 4.02 | 4.02 |
397.44 | 3.57 | 3.57 |
460.93 | 4.32 | 4.32 |
425.50 | 4.43 | 4.43 |
557.63 | 5.14 | 5.14 |
480.58 | 4.41 | 4.41 |
430.90 | 4.83 | 4.83 |
451.53 | 4.52 | 4.52 |
471.95 | 4.78 | 4.78 |
465.56 | 4.69 | 4.69 |
549.64 | 4.64 | 4.64 |
515.57 | 5.32 | 5.32 |
576.71 | 4.85 | 4.85 |
446.90 | 3.80 | 3.80 |
412.46 | 3.15 | 3.15 |
494.60 | 4.06 | 4.06 |
398.43 | 2.96 | 2.96 |
503.61 | 4.67 | 4.67 |
465.52 | 3.94 | 3.94 |
444.50 | 1.60 | 1.60 |
551.94 | 4.28 | 4.28 |
513.56 | 2.02 | 2.02 |
532.61 | 4.82 | 4.82 |
496.57 | 4.95 | 4.95 |
432.88 | 3.62 | 3.62 |
560.67 | 3.90 | 3.90 |
445.91 | 4.32 | 4.32 |
509.80 | 5.59 | 5.59 |
437.92 | 4.28 | 4.28 |
468.52 | 3.57 | 3.57 |
470.96 | 5.61 | 5.61 |
524.63 | 3.83 | 3.83 |
437.51 | 4.13 | 4.13 |
428.93 | 5.03 | 5.03 |
519.61 | 4.55 | 4.55 |
465.56 | 5.36 | 5.36 |
514.44 | 4.84 | 4.84 |
546.64 | 3.68 | 3.68 |
520.35 | 3.70 | 3.70 |
562.64 | 3.72 | 3.72 |
466.51 | 3.69 | 3.69 |
488.39 | 4.99 | 4.99 |
457.93 | 4.39 | 4.39 |
557.63 | 5.14 | 5.14 |
479.59 | 5.01 | 5.01 |
574.74 | 4.69 | 4.69 |
494.60 | 3.84 | 3.84 |
545.65 | 5.09 | 5.09 |
491.64 | 6.09 | 6.09 |
494.56 | 3.98 | 3.98 |
514.59 | 2.46 | 2.46 |
481.56 | 3.92 | 3.92 |
478.97 | 4.24 | 4.24 |
465.56 | 5.08 | 5.08 |
505.63 | 5.78 | 5.78 |
395.47 | 3.77 | 3.77 |
503.61 | 4.74 | 4.74 |
511.59 | 2.79 | 2.79 |
539.55 | 4.38 | 4.38 |
529.60 | 5.41 | 5.41 |
521.56 | 4.08 | 4.08 |
525.41 | 2.61 | 2.61 |
423.48 | 3.94 | 3.94 |
445.91 | 4.61 | 4.61 |
446.52 | 1.85 | 1.85 |
431.89 | 4.22 | 4.22 |
539.64 | 3.16 | 3.16 |
479.59 | 5.01 | 5.01 |
491.60 | 4.79 | 4.79 |
525.57 | 2.43 | 2.43 |
471.95 | 5.00 | 5.00 |
540.63 | 4.39 | 4.39 |
396.45 | 4.17 | 4.17 |
460.93 | 4.26 | 4.26 |
475.56 | 4.17 | 4.17 |
539.62 | 5.29 | 5.29 |
503.01 | 4.46 | 4.46 |
550.71 | 5.12 | 5.12 |
480.57 | 5.25 | 5.25 |
517.55 | 3.66 | 3.66 |
553.55 | 4.15 | 4.15 |
467.53 | 4.42 | 4.42 |
462.31 | 3.87 | 3.87 |
426.48 | 3.61 | 3.61 |
467.53 | 4.42 | 4.42 |
425.50 | 4.23 | 4.23 |
501.57 | 3.14 | 3.14 |
501.60 | 4.34 | 4.34 |
443.54 | 4.19 | 4.19 |
485.57 | 3.47 | 3.47 |
396.45 | 4.02 | 4.02 |
468.57 | 3.67 | 3.67 |
508.63 | 4.77 | 4.77 |