Basic Information
ID: ALA5053464
Type: Binding
Description: Inhibition of APOL1 G1 variant in human HEK293-T-REx cells measured by Thallium assay
Organism: Homo sapiens
Cell type: HEK293-T-REx
Activity Charts
Bioactivity
Activity Types for Assay ALA5053464
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 432.44 | 3.60 | 3.60 |
| 470.41 | 5.18 | 5.18 |
| 459.47 | 3.81 | 3.81 |
| 444.45 | 4.36 | 4.36 |
| 426.44 | 4.98 | 4.98 |
| 426.44 | 4.98 | 4.98 |
| 457.50 | 3.88 | 3.88 |
| 442.48 | 5.12 | 5.12 |
| 416.44 | 4.59 | 4.59 |
| 387.40 | 3.96 | 3.96 |
| 487.52 | 4.58 | 4.58 |
| 442.48 | 4.98 | 4.98 |
| 432.44 | 3.61 | 3.61 |
| 478.46 | 5.10 | 5.10 |
| 448.44 | 3.97 | 3.97 |
| 401.43 | 4.21 | 4.21 |
| 485.43 | 4.97 | 4.97 |
| 446.47 | 3.68 | 3.68 |
| 387.41 | 3.82 | 3.82 |
| 404.39 | 4.22 | 4.22 |
| 434.41 | 3.58 | 3.58 |
| 442.44 | 4.25 | 4.25 |
| 432.44 | 5.00 | 5.00 |
| 471.52 | 4.27 | 4.27 |
| 446.47 | 3.95 | 3.95 |
| 441.41 | 3.28 | 3.28 |
| 466.51 | 5.43 | 5.43 |
| 430.47 | 4.98 | 4.98 |
| 415.46 | 4.60 | 4.60 |
| 454.45 | 5.16 | 5.16 |
| 443.43 | 4.11 | 4.11 |
| 417.43 | 3.18 | 3.18 |
| 438.45 | 4.80 | 4.80 |
| 439.44 | 4.15 | 4.15 |
| 466.51 | 5.18 | 5.18 |
| 428.45 | 5.04 | 5.04 |
| 454.45 | 4.83 | 4.83 |
| 445.49 | 4.77 | 4.77 |
| 512.53 | 4.93 | 4.93 |
| 402.42 | 4.24 | 4.24 |
| 388.39 | 3.85 | 3.85 |
| 400.40 | 5.39 | 5.39 |
| 432.44 | 3.56 | 3.56 |
| 431.41 | 2.71 | 2.71 |
| 417.43 | 4.18 | 4.18 |
| 414.43 | 4.39 | 4.39 |
| 444.45 | 3.56 | 3.56 |
| 451.45 | 5.15 | 5.15 |
| 441.41 | 5.41 | 5.41 |
| 442.48 | 4.98 | 4.98 |
| 418.42 | 3.22 | 3.22 |
| 455.44 | 4.55 | 4.55 |
| 430.47 | 4.88 | 4.88 |
| 416.44 | 4.63 | 4.63 |
| 481.52 | 5.32 | 5.32 |
| 401.43 | 4.08 | 4.08 |
| 432.44 | 4.99 | 4.99 |
| 445.49 | 4.77 | 4.77 |
| 432.44 | 5.26 | 5.26 |
| 445.49 | 4.77 | 4.77 |
| 416.44 | 4.59 | 4.59 |
| 454.49 | 5.72 | 5.72 |
| 455.48 | 4.07 | 4.07 |
| 469.51 | 4.83 | 4.83 |
| 444.45 | 3.97 | 3.97 |
| 415.46 | 4.42 | 4.42 |
| 459.47 | 3.36 | 3.36 |
| 426.36 | 5.42 | 5.42 |
| 414.43 | 4.34 | 4.34 |
| 414.43 | 4.65 | 4.65 |
| 470.41 | 5.18 | 5.18 |
| 440.43 | 4.75 | 4.75 |
| 446.47 | 3.95 | 3.95 |
| 418.42 | 3.22 | 3.22 |
| 427.43 | 3.75 | 3.75 |
| 452.48 | 5.19 | 5.19 |
| 414.43 | 5.63 | 5.63 |
| 414.43 | 4.39 | 4.39 |
| 428.45 | 4.73 | 4.73 |
| 473.50 | 4.15 | 4.15 |
| 418.42 | 4.61 | 4.61 |
| 445.44 | 2.97 | 2.97 |
| 452.48 | 5.07 | 5.07 |
| 432.44 | 5.26 | 5.26 |
| 442.48 | 5.12 | 5.12 |
| 466.51 | 5.18 | 5.18 |
| 442.48 | 4.85 | 4.85 |
| 418.42 | 3.22 | 3.22 |
| 456.51 | 5.51 | 5.51 |
| 401.43 | 4.21 | 4.21 |
| 418.42 | 3.22 | 3.22 |
| 402.37 | 3.95 | 3.95 |
| 442.48 | 4.98 | 4.98 |
| 442.48 | 5.12 | 5.12 |
| 428.45 | 4.99 | 4.99 |
| 441.41 | 3.28 | 3.28 |
| 415.46 | 4.47 | 4.47 |
| 429.44 | 3.19 | 3.19 |
| 344.34 | 4.23 | 4.23 |
| 424.37 | 5.49 | 5.49 |
| 457.50 | 4.96 | 4.96 |
| 452.48 | 4.87 | 4.87 |
| 448.44 | 5.91 | 5.91 |
| 413.40 | 3.75 | 3.75 |
| 428.45 | 4.73 | 4.73 |
| 417.43 | 3.40 | 3.40 |
| 444.50 | 5.10 | 5.10 |
| 414.43 | 4.65 | 4.65 |
| 452.48 | 5.07 | 5.07 |
| 443.43 | 2.72 | 2.72 |
| 451.39 | 4.23 | 4.23 |
| 428.45 | 4.78 | 4.78 |
| 443.47 | 4.07 | 4.07 |
| 427.43 | 3.75 | 3.75 |
| 432.44 | 3.87 | 3.87 |
| 432.44 | 3.61 | 3.61 |
| 441.45 | 4.22 | 4.22 |
| 444.45 | 3.97 | 3.97 |
| 456.51 | 5.37 | 5.37 |
| 443.47 | 4.57 | 4.57 |
| 430.47 | 4.98 | 4.98 |
| 471.48 | 4.75 | 4.75 |
| 438.45 | 5.73 | 5.73 |
| 438.45 | 4.80 | 4.80 |
| 428.45 | 4.73 | 4.73 |
| 414.43 | 4.65 | 4.65 |
| 420.41 | 4.19 | 4.19 |
| 402.42 | 4.51 | 4.51 |
| 426.36 | 5.42 | 5.42 |
| 443.51 | 5.24 | 5.24 |
| 440.42 | 6.02 | 6.02 |
| 457.45 | 3.11 | 3.11 |
| 416.44 | 4.63 | 4.63 |
| 414.43 | 4.65 | 4.65 |
| 424.43 | 4.79 | 4.79 |
| 553.63 | 5.36 | 5.36 |
| 472.51 | 4.74 | 4.74 |
| 429.49 | 4.81 | 4.81 |
| 456.51 | 5.37 | 5.37 |
| 483.41 | 4.67 | 4.67 |
| 441.45 | 4.09 | 4.09 |
| 443.47 | 4.57 | 4.57 |
| 402.42 | 4.24 | 4.24 |
| 442.48 | 4.98 | 4.98 |
| 416.44 | 4.63 | 4.63 |
| 428.45 | 4.73 | 4.73 |
| 441.45 | 4.08 | 4.08 |
| 439.44 | 4.15 | 4.15 |
| 402.42 | 4.20 | 4.20 |
| 428.45 | 4.73 | 4.73 |
| 428.45 | 4.78 | 4.78 |
| 402.42 | 4.24 | 4.24 |
| 430.43 | 3.92 | 3.92 |
| 456.51 | 5.24 | 5.24 |
| 458.48 | 4.09 | 4.09 |
| 416.44 | 4.32 | 4.32 |
| 473.50 | 4.20 | 4.20 |
| 442.48 | 5.29 | 5.29 |
| 402.42 | 3.93 | 3.93 |
| 416.44 | 4.49 | 4.49 |
| 427.43 | 3.82 | 3.82 |
| 427.47 | 5.50 | 5.50 |
| 485.51 | 5.14 | 5.14 |
| 432.44 | 3.60 | 3.60 |
| 458.52 | 5.34 | 5.34 |
| 388.39 | 3.85 | 3.85 |
| 438.45 | 4.80 | 4.80 |
| 441.45 | 4.14 | 4.14 |
| 432.42 | 4.48 | 4.48 |
| 428.45 | 4.73 | 4.73 |
| 417.43 | 4.18 | 4.18 |
| 439.44 | 4.15 | 4.15 |
| 387.41 | 4.67 | 4.67 |
| 452.48 | 5.10 | 5.10 |
| 499.53 | 3.65 | 3.65 |
| 443.47 | 4.34 | 4.34 |
| 456.51 | 5.36 | 5.36 |
| 455.48 | 4.22 | 4.22 |
| 448.44 | 5.91 | 5.91 |
| 433.43 | 3.15 | 3.15 |
| 428.45 | 4.73 | 4.73 |
| 358.36 | 4.62 | 4.62 |
| 450.46 | 5.03 | 5.03 |
| 427.43 | 3.88 | 3.88 |
| 427.43 | 3.70 | 3.70 |
| 426.40 | 4.45 | 4.45 |
| 414.43 | 4.39 | 4.39 |
| 457.50 | 4.76 | 4.76 |
| 493.48 | 5.21 | 5.21 |
| 441.45 | 4.14 | 4.14 |
| 401.39 | 3.35 | 3.35 |
| 428.45 | 4.73 | 4.73 |
| 416.44 | 4.32 | 4.32 |
| 456.39 | 4.79 | 4.79 |
| 402.42 | 4.24 | 4.24 |
| 430.43 | 4.75 | 4.75 |
| 432.44 | 3.60 | 3.60 |
| 402.42 | 4.24 | 4.24 |
| 441.45 | 4.14 | 4.14 |
| 470.41 | 4.86 | 4.86 |
| 414.43 | 4.39 | 4.39 |
| 439.44 | 5.13 | 5.13 |
| 442.48 | 4.97 | 4.97 |
| 443.43 | 2.72 | 2.72 |
| 428.45 | 4.99 | 4.99 |
| 438.45 | 4.80 | 4.80 |
| 416.44 | 4.63 | 4.63 |
| 427.43 | 3.75 | 3.75 |
| 457.50 | 4.96 | 4.96 |
| 442.48 | 5.12 | 5.12 |
| 416.44 | 4.63 | 4.63 |
| 403.40 | 3.15 | 3.15 |
| 414.43 | 4.39 | 4.39 |
| 427.43 | 3.75 | 3.75 |
| 431.46 | 4.43 | 4.43 |
| 416.44 | 4.59 | 4.59 |
| 427.43 | 3.75 | 3.75 |
| 428.45 | 4.78 | 4.78 |
| 470.49 | 4.50 | 4.50 |
| 428.45 | 4.78 | 4.78 |
| 448.44 | 2.58 | 2.58 |
| 444.50 | 5.10 | 5.10 |
| 446.43 | 3.98 | 3.98 |
| 484.52 | 5.15 | 5.15 |
| 456.39 | 4.79 | 4.79 |
| 414.43 | 4.65 | 4.65 |
| 387.41 | 3.83 | 3.83 |
| 513.44 | 3.90 | 3.90 |
| 428.45 | 4.73 | 4.73 |
| 415.46 | 4.61 | 4.61 |
| 456.51 | 5.56 | 5.56 |
| 457.50 | 4.96 | 4.96 |
| 455.48 | 4.47 | 4.47 |
| 428.45 | 4.63 | 4.63 |
| 499.53 | 5.53 | 5.53 |
| 454.45 | 6.33 | 6.33 |
| 437.46 | 5.36 | 5.36 |
| 439.44 | 5.36 | 5.36 |
| 470.54 | 4.11 | 4.11 |
| 415.42 | 3.74 | 3.74 |
| 443.47 | 4.29 | 4.29 |
| 462.46 | 5.98 | 5.98 |
| 414.43 | 4.39 | 4.39 |
| 441.45 | 4.00 | 4.00 |
| 446.47 | 3.99 | 3.99 |
| 430.43 | 3.31 | 3.31 |
| 442.48 | 5.17 | 5.17 |
| 431.46 | 4.43 | 4.43 |
| 428.45 | 4.78 | 4.78 |
| 428.45 | 4.78 | 4.78 |
| 448.44 | 2.58 | 2.58 |
| 428.41 | 4.18 | 4.18 |
| 414.43 | 4.39 | 4.39 |
| 464.51 | 3.98 | 3.98 |
| 429.49 | 4.81 | 4.81 |
| 456.51 | 5.51 | 5.51 |
| 472.51 | 4.34 | 4.34 |
| 455.48 | 4.34 | 4.34 |
| 428.45 | 4.78 | 4.78 |
| 485.43 | 4.97 | 4.97 |
| 387.41 | 3.82 | 3.82 |
| 442.44 | 3.69 | 3.69 |
| 442.48 | 5.12 | 5.12 |
| 441.45 | 4.14 | 4.14 |
| 458.48 | 3.95 | 3.95 |
| 440.43 | 4.75 | 4.75 |
| 443.47 | 3.54 | 3.54 |
| 428.45 | 4.78 | 4.78 |
| 473.50 | 4.05 | 4.05 |
| 418.42 | 4.61 | 4.61 |
| 427.43 | 3.75 | 3.75 |
| 417.39 | 3.71 | 3.71 |
| 452.48 | 4.87 | 4.87 |
| 470.50 | 4.32 | 4.32 |
| 465.48 | 4.83 | 4.83 |
| 418.42 | 4.61 | 4.61 |
| 464.44 | 2.94 | 2.94 |
| 470.50 | 4.18 | 4.18 |
| 442.48 | 4.98 | 4.98 |
| 469.51 | 4.87 | 4.87 |
| 445.49 | 4.82 | 4.82 |
| 443.47 | 4.34 | 4.34 |
| 443.43 | 4.11 | 4.11 |
| 432.44 | 5.00 | 5.00 |
| 442.48 | 4.98 | 4.98 |
| 499.53 | 4.50 | 4.50 |
| 444.45 | 5.40 | 5.40 |
| 424.43 | 5.12 | 5.12 |
| 456.51 | 5.37 | 5.37 |
| 401.43 | 5.02 | 5.02 |
| 445.49 | 4.77 | 4.77 |
| 402.42 | 4.24 | 4.24 |
| 456.51 | 5.36 | 5.36 |
| 402.42 | 4.24 | 4.24 |
| 428.45 | 4.78 | 4.78 |
| 417.43 | 3.18 | 3.18 |
| 442.48 | 5.29 | 5.29 |
| 438.40 | 4.49 | 4.49 |
| 443.47 | 4.57 | 4.57 |
| 442.48 | 4.85 | 4.85 |
| 441.45 | 4.14 | 4.14 |
| 455.44 | 3.67 | 3.67 |
| 417.43 | 4.04 | 4.04 |
| 456.51 | 5.37 | 5.37 |
| 414.43 | 4.34 | 4.34 |
| 431.46 | 4.36 | 4.36 |
| 416.44 | 4.63 | 4.63 |
| 464.43 | 5.02 | 5.02 |
| 427.43 | 4.14 | 4.14 |
| 416.44 | 4.63 | 4.63 |
| 409.36 | 4.63 | 4.63 |
| 430.43 | 5.01 | 5.01 |
| 469.51 | 4.87 | 4.87 |
| 416.44 | 4.90 | 4.90 |
| 443.47 | 4.57 | 4.57 |
| 431.41 | 2.71 | 2.71 |
| 457.50 | 4.91 | 4.91 |
| 418.42 | 4.61 | 4.61 |
| 373.38 | 3.57 | 3.57 |
| 430.43 | 5.01 | 5.01 |
| 474.52 | 4.78 | 4.78 |
| 430.47 | 4.88 | 4.88 |
| 425.41 | 5.68 | 5.68 |
| 473.54 | 5.45 | 5.45 |
| 438.40 | 4.73 | 4.73 |
| 456.39 | 4.79 | 4.79 |
| 373.38 | 4.38 | 4.38 |
| 456.51 | 5.36 | 5.36 |
| 452.48 | 5.36 | 5.36 |
| 402.42 | 4.24 | 4.24 |
| 446.47 | 5.24 | 5.24 |
| 441.45 | 4.14 | 4.14 |
| 445.49 | 4.82 | 4.82 |
| 418.42 | 4.61 | 4.61 |
| 456.44 | 4.89 | 4.89 |
| 444.45 | 5.26 | 5.26 |
| 432.44 | 3.61 | 3.61 |
| 444.45 | 5.14 | 5.14 |
| 431.41 | 2.71 | 2.71 |
| 414.43 | 4.39 | 4.39 |
| 412.41 | 3.86 | 3.86 |
| 440.47 | 4.99 | 4.99 |
| 444.45 | 4.05 | 4.05 |
| 439.44 | 5.13 | 5.13 |
| 456.51 | 5.68 | 5.68 |
| 425.41 | 5.68 | 5.68 |
| 440.43 | 4.48 | 4.48 |
| 442.44 | 4.57 | 4.57 |
| 373.38 | 3.57 | 3.57 |
| 429.49 | 4.86 | 4.86 |
| 497.48 | 5.79 | 5.79 |
| 430.43 | 3.62 | 3.62 |
| 446.47 | 5.24 | 5.24 |
| 416.44 | 4.59 | 4.59 |
| 418.42 | 3.22 | 3.22 |
| 414.43 | 4.20 | 4.20 |
| 430.47 | 4.88 | 4.88 |
| 484.52 | 3.64 | 3.64 |
| 430.47 | 4.98 | 4.98 |
| 427.43 | 3.70 | 3.70 |
| 442.48 | 4.85 | 4.85 |
| 402.42 | 4.51 | 4.51 |
| 486.53 | 4.99 | 4.99 |
| 441.45 | 4.22 | 4.22 |
| 432.44 | 3.60 | 3.60 |
| 430.43 | 5.01 | 5.01 |
| 486.53 | 5.14 | 5.14 |
| 413.44 | 4.37 | 4.37 |
| 456.39 | 4.79 | 4.79 |
| 438.45 | 4.80 | 4.80 |
| 450.48 | 3.91 | 3.91 |
| 441.45 | 4.14 | 4.14 |
| 408.37 | 5.13 | 5.13 |
| 444.45 | 3.97 | 3.97 |
| 387.41 | 3.82 | 3.82 |
| 441.45 | 4.08 | 4.08 |
| 438.45 | 4.86 | 4.86 |
| 428.45 | 4.78 | 4.78 |
| 437.46 | 5.36 | 5.36 |
| 455.44 | 5.72 | 5.72 |
| 430.43 | 3.31 | 3.31 |
| 430.47 | 4.71 | 4.71 |
| 445.49 | 4.82 | 4.82 |
| 428.45 | 4.78 | 4.78 |
| 414.43 | 4.39 | 4.39 |
| 442.48 | 4.71 | 4.71 |
| 438.45 | 4.80 | 4.80 |
| 485.43 | 4.97 | 4.97 |
| 520.48 | 5.90 | 5.90 |
| 458.48 | 4.36 | 4.36 |
| 444.45 | 4.01 | 4.01 |
| 444.45 | 3.87 | 3.87 |
| 457.50 | 4.76 | 4.76 |
| 440.43 | 5.15 | 5.15 |
| 461.48 | 3.79 | 3.79 |
| 415.42 | 3.74 | 3.74 |
| 448.44 | 3.97 | 3.97 |
| 414.43 | 4.34 | 4.34 |
| 401.39 | 3.35 | 3.35 |
| 456.51 | 5.36 | 5.36 |
| 452.48 | 4.87 | 4.87 |
| 442.48 | 5.17 | 5.17 |
| 416.44 | 4.63 | 4.63 |
| 443.47 | 4.57 | 4.57 |
| 426.44 | 4.98 | 4.98 |
| 439.44 | 4.19 | 4.19 |
| 452.42 | 4.56 | 4.56 |
| 452.48 | 5.36 | 5.36 |
| 414.43 | 4.51 | 4.51 |
| 468.48 | 4.93 | 4.93 |
| 469.43 | 5.14 | 5.14 |
| 424.43 | 5.12 | 5.12 |
| 444.45 | 3.96 | 3.96 |
| 429.44 | 4.00 | 4.00 |
| 522.45 | 6.18 | 6.18 |
| 427.47 | 4.61 | 4.61 |
| 440.47 | 4.59 | 4.59 |
| 454.49 | 5.12 | 5.12 |
| 455.44 | 3.67 | 3.67 |
| 428.45 | 4.59 | 4.59 |
| 452.48 | 4.87 | 4.87 |
| 415.42 | 3.69 | 3.69 |
| 417.43 | 4.11 | 4.11 |
| 472.39 | 5.15 | 5.15 |
| 485.55 | 4.52 | 4.52 |
| 466.46 | 4.56 | 4.56 |
| 344.34 | 4.23 | 4.23 |
| 448.44 | 3.97 | 3.97 |
| 431.41 | 2.71 | 2.71 |
| 401.43 | 5.06 | 5.06 |
| 431.46 | 4.43 | 4.43 |
| 438.40 | 4.49 | 4.49 |
| 402.42 | 4.24 | 4.24 |
| 440.47 | 4.44 | 4.44 |
| 428.45 | 4.78 | 4.78 |
| 455.44 | 5.72 | 5.72 |
| 442.48 | 5.12 | 5.12 |
| 402.42 | 4.24 | 4.24 |
| 431.46 | 4.38 | 4.38 |
| 429.44 | 4.13 | 4.13 |
| 425.41 | 5.05 | 5.05 |
| 513.44 | 3.90 | 3.90 |
| 402.42 | 4.24 | 4.24 |
| 441.45 | 4.14 | 4.14 |
| 440.47 | 4.73 | 4.73 |
| 402.42 | 4.24 | 4.24 |
| 465.48 | 4.83 | 4.83 |
| 444.45 | 3.97 | 3.97 |
| 458.52 | 5.34 | 5.34 |
| 422.43 | 3.82 | 3.82 |