Basic Information
ID: ALA5057866
Type: Binding
Description: Inhibition of human recombinant PDHK4 co-complexed with porcine PDH using sodium pyruvate, coenzymeA and NAD as substrates preincubated with enzyme complex for 45 mins followed by substrates addition and further incubated for 90 mins in presence of ATP at Km concentration by spectrophotometric assay
Format: BAO_0000357
Organism: Homo sapiens
Target: Pyruvate dehydrogenase kinase isoform 4(ALA4141)
Document: ALA5055678
Inhibition of human recombinant PDHK4 co-complexed with porcine PDH using sodium pyruvate, coenzymeA and NAD as substrates preincubated with enzyme complex for 45 mins followed by substrates addition and further incubated for 90 mins in presence of ATP at Km concentration by spectrophotometric assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA5057866
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 445.91 | 5.36 | 5.36 |
| 292.39 | 3.90 | 3.90 |
| 332.41 | 5.08 | 5.08 |
| 430.51 | 3.08 | 3.08 |
| 280.33 | 3.69 | 3.69 |
| 298.39 | 5.57 | 5.57 |
| 299.38 | 4.96 | 4.96 |
| 320.44 | 4.68 | 4.68 |
| 318.38 | 4.51 | 4.51 |
| 322.41 | 3.26 | 3.26 |
| 493.61 | 6.40 | 6.40 |
| 455.56 | 3.58 | 3.58 |
| 346.43 | 5.15 | 5.15 |
| 279.34 | 3.26 | 3.26 |
| 398.51 | 4.65 | 4.65 |
| 304.35 | 4.26 | 4.26 |
| 332.41 | 4.90 | 4.90 |
| 431.50 | 3.68 | 3.68 |
| 493.61 | 6.40 | 6.40 |
| 429.52 | 5.10 | 5.10 |
| 507.64 | 6.96 | 6.96 |
| 360.46 | 5.71 | 5.71 |
| 334.45 | 4.98 | 4.98 |
| 442.56 | 4.09 | 4.09 |
| 222.29 | 3.90 | 3.90 |
| 322.41 | 3.26 | 3.26 |
| 412.54 | 4.73 | 4.73 |