Basic Information
ID: ALA5096975
Type: Binding
Description: Inhibition of N-terminal 6His-tagged full-length H2N-VE(pY)LDLDLD(PEG8)RVD(pY)VVVDQQ-amide-activated SHP2 (247 to 529 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using DiFMUP as substrate preincubated for 10 to 30 mins with activating peptide prior to compound addition for 30 mins followed by substrate addition and measured for 6 mins by fluorescence based assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5096975
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 437.37 | 3.58 | 3.58 |
| 451.38 | 3.76 | 3.76 |