Basic Information
ID: ALA5098594
Type: Binding
Description: Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluorogenic 6,8-difluoro-4-methylumbelliferyl phosphate as substrate pretreated for 30 mins followed by substrate addition and measured after 1 hr by fluorescence assay
Format: BAO_0000219
Organism: Homo sapiens
Target: Protein-tyrosine phosphatase 2C(ALA3864)
Document: ALA5096203
Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluorogenic 6,8-difluoro-4-methylumbelliferyl phosphate as substrate pretreated for 30 mins followed by substrate addition and measured after 1 hr by fluorescence assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA5098594
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 433.34 | 3.66 | 3.66 |
| 372.86 | 2.43 | 2.43 |
| 367.28 | 3.17 | 3.17 |
| 388.90 | 2.53 | 2.53 |
| 327.19 | 0.73 | 0.73 |
| 378.26 | 3.86 | 3.86 |
| 433.34 | 3.72 | 3.72 |
| 368.27 | 2.44 | 2.44 |
| 359.82 | 1.68 | 1.68 |
| 487.01 | 2.72 | 2.72 |
| 437.37 | 3.24 | 3.24 |
| 393.28 | 2.94 | 2.94 |
| 433.34 | 3.72 | 3.72 |
| 421.33 | 3.54 | 3.54 |
| 423.44 | 2.29 | 2.29 |
| 424.36 | 3.71 | 3.71 |
| 324.39 | 1.63 | 1.63 |
| 463.37 | 3.15 | 3.15 |
| 442.96 | 2.83 | 2.83 |
| 392.39 | 2.65 | 2.65 |
| 432.96 | 2.35 | 2.35 |
| 453.37 | 2.67 | 2.67 |
| 457.79 | 3.83 | 3.83 |
| 358.83 | 2.28 | 2.28 |
| 419.32 | 3.27 | 3.27 |
| 377.28 | 3.64 | 3.64 |
| 417.34 | 4.42 | 4.42 |
| 393.37 | 2.04 | 2.04 |
| 407.31 | 3.19 | 3.19 |
| 423.34 | 3.18 | 3.18 |
| 358.83 | 2.28 | 2.28 |
| 491.34 | 4.20 | 4.20 |
| 423.37 | 4.32 | 4.32 |
| 392.29 | 3.54 | 3.54 |
| 388.90 | 2.53 | 2.53 |
| 448.35 | 3.05 | 3.05 |
| 394.27 | 2.33 | 2.33 |
| 466.37 | 2.28 | 2.28 |
| 440.43 | 5.05 | 5.05 |
| 388.90 | 2.53 | 2.53 |
| 407.31 | 3.20 | 3.20 |
| 447.25 | 3.48 | 3.48 |