Basic Information
ID: ALA5100433
Type: Binding
Description: Positive allosteric modulator activity in wild type human A3AR opioid receptor stably expressed in human HEK293 cell membrane assessed as increase in CI-IB-MECA induced [35S]GTPGAgammaS binding to receptor at 1 uM preincubated for 1 hrs with CI-IB-MECA further incubated with [35S]GTPGAgammaS for 2 hrs in presence of PSB-603,ZM241385 and ADP to degrade endogenous AR by liquid scintillation spectrometry
Organism: Homo sapiens
Cell type: HEK293
Subcellular Fraction: Cell membrane
Activity Charts
Bioactivity
Activity Types for Assay ALA5100433
Emax
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 411.34 | 7.21 | 7.21 |
| 383.28 | 6.43 | 6.43 |
| 397.31 | 6.82 | 6.82 |
| 425.36 | 7.60 | 7.60 |
| 421.34 | 6.66 | 6.66 |
| 495.50 | 9.55 | 9.55 |
| 484.39 | 7.14 | 7.14 |
| 427.38 | 7.85 | 7.85 |
| 451.40 | 7.85 | 7.85 |
| 371.27 | 6.11 | 6.11 |
| 369.26 | 6.04 | 6.04 |
| 451.40 | 7.77 | 7.77 |
| 439.35 | 6.59 | 6.59 |
| 426.52 | 6.09 | 6.09 |
| 441.36 | 6.57 | 6.57 |
| 439.39 | 7.99 | 7.99 |
| 453.42 | 8.38 | 8.38 |
| 535.32 | 8.93 | 8.93 |
| 467.44 | 8.77 | 8.77 |
| 439.35 | 6.78 | 6.78 |
| 483.04 | 8.02 | 8.02 |
| 395.29 | 6.28 | 6.28 |
| 521.30 | ||
| 423.35 | 7.38 | 7.38 |
| 479.33 | 8.00 | 8.00 |
| 481.47 | 9.16 | 9.16 |
| 468.34 | 6.51 | 6.51 |
| 439.35 | 6.59 | 6.59 |
| 647.54 | ||
| 437.37 | 7.46 | 7.46 |
| 435.36 | 7.23 | 7.23 |
| 423.35 | 6.99 | 6.99 |