Basic Information
ID: ALA5100435
Type: Binding
Description: Positive allosteric modulator activity in wild type human A3AR opioid receptor stably expressed in human HEK293 cell membrane assessed as increase in CI-IB-MECA induced [35S]GTPGAgammaS binding to receptor at 0.1 uM preincubated for 1 hrs with CI-IB-MECA further incubated with [35S]GTPGAgammaS for 2 hrs in presence of PSB-603,ZM241385 and ADP to degrade endogenous AR by liquid scintillation spectrometry
Organism: Homo sapiens
Cell type: HEK293
Subcellular Fraction: Cell membrane
Activity Charts
Bioactivity
Activity Types for Assay ALA5100435
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 439.35 | 6.59 | 6.59 |
| 441.36 | 6.57 | 6.57 |
| 439.35 | 6.78 | 6.78 |
| 439.35 | 6.59 | 6.59 |