Basic Information
ID: ALA5107642
Type: Binding
Description: Inhibition of recombinant SARS-CoV-2 3CLpro expressed in Escherichia coli NiCo21(DE3) assessed as residual activity at 500 uM using DABCYL-KTSAVLQSGFRKME-EDANS as substrate preincubated for 30 mins in presence of 1mM DTT followed by substrate addition and measured by FRET assay relative to control
Organism: Severe acute respiratory syndrome coronavirus 2
Activity Charts
Bioactivity
Activity Types for Assay ALA5107642
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 255.32 | 1.53 | 1.53 |
| 158.18 | 0.35 | 0.35 |
| 100.15 | 0.73 | 0.73 |
| 254.34 | 2.08 | 2.08 |
| 114.17 | 1.03 | 1.03 |
| 114.17 | 1.03 | 1.03 |
| 177.23 | 1.79 | 1.79 |
| 115.16 | 0.43 | 0.43 |
| 169.13 | 1.14 | 1.14 |
| 186.24 | 0.83 | 0.83 |
| 172.21 | 0.90 | 0.90 |
| 219.26 | 2.82 | 2.82 |
| 183.16 | 1.60 | 1.60 |
| 156.25 | 2.02 | 2.02 |
| 164.03 | 1.91 | 1.91 |
| 119.58 | 1.80 | 1.80 |
| 223.23 | 2.65 | 2.65 |
| 165.01 | 1.30 | 1.30 |
| 225.23 | 0.52 | 0.52 |
| 271.30 | 3.13 | 3.13 |
| 209.28 | 0.28 | 0.28 |
| 236.09 | 2.08 | 2.08 |
| 189.04 | 1.78 | 1.78 |
| 206.23 | 1.90 | 1.90 |
| 276.11 | 3.85 | 3.85 |
| 222.06 | 1.91 | 1.91 |
| 144.16 | 0.42 | 0.42 |
| 179.04 | 1.49 | 1.49 |
| 222.06 | 1.69 | 1.69 |
| 222.06 | 1.53 | 1.53 |
| 178.05 | 2.21 | 2.21 |
| 143.17 | 1.15 | 1.15 |
| 208.04 | 1.60 | 1.60 |
| 208.04 | 1.60 | 1.60 |
| 141.20 | 1.00 | 1.00 |
| 279.12 | 1.41 | 1.41 |
| 222.06 | 1.69 | 1.69 |
| 147.63 | 2.19 | 2.19 |
| 251.06 | 0.93 | 0.93 |
| 211.20 | 0.43 | 0.43 |
| 141.19 | 1.65 | 1.65 |
| 265.09 | 1.02 | 1.02 |
| 250.12 | 2.39 | 2.39 |
| 236.09 | 2.08 | 2.08 |
| 125.16 | 0.60 | 0.60 |
| 250.12 | 2.01 | 2.01 |
| 208.04 | 1.60 | 1.60 |
| 197.18 | 0.04 | 0.04 |
| 242.92 | 2.67 | 2.67 |