Basic Information
ID: ALA5110183
Type: Binding
Description: Inhibition of N-terminal hexa-histidine tagged human TDO (19 to 388 residues) expressed in Escherichia coli Transetta (DE3) using L-tryptophan as substrate at 100 uM preincubated with enzyme for 10 mins followed by substrate addition and measured after 30 to 60 mins by microplate reader analysis relative to control
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5110183
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 348.33 | 3.55 | 3.55 |
| 283.29 | 2.45 | 2.45 |
| 379.34 | 3.53 | 3.53 |
| 404.44 | 4.91 | 4.91 |
| 359.27 | 5.21 | 5.21 |
| 335.29 | 3.89 | 3.89 |
| 363.17 | 3.55 | 3.55 |
| 442.40 | 5.68 | 5.68 |
| 298.31 | 3.14 | 3.14 |
| 268.28 | 3.08 | 3.08 |
| 326.31 | 2.87 | 2.87 |
| 336.27 | 4.10 | 4.10 |
| 347.17 | 3.85 | 3.85 |
| 336.27 | 4.10 | 4.10 |
| 433.16 | 5.00 | 5.00 |
| 415.37 | 3.40 | 3.40 |
| 370.72 | 4.76 | 4.76 |
| 347.37 | 5.41 | 5.41 |
| 375.31 | 4.58 | 4.58 |
| 336.27 | 4.10 | 4.10 |
| 347.17 | 3.85 | 3.85 |
| 341.72 | 4.55 | 4.55 |
| 407.22 | 3.86 | 3.86 |
| 298.31 | 3.14 | 3.14 |
| 378.35 | 5.16 | 5.16 |
| 371.73 | 4.65 | 4.65 |
| 306.29 | 3.78 | 3.78 |
| 270.26 | 2.21 | 2.21 |
| 293.29 | 2.95 | 2.95 |
| 347.17 | 3.85 | 3.85 |
| 297.27 | 2.09 | 2.09 |
| 307.27 | 3.90 | 3.90 |
| 284.29 | 2.75 | 2.75 |
| 370.72 | 4.76 | 4.76 |
| 347.17 | 3.85 | 3.85 |
| 351.31 | 4.30 | 4.30 |
| 364.33 | 3.69 | 3.69 |
| 370.17 | 4.96 | 4.96 |