Basic Information
ID: ALA5110185
Type: Binding
Description: Inhibition of N-terminal hexa-histidine tagged human TDO (19 to 388 residues) expressed in Escherichia coli Transetta (DE3) using L-tryptophan as substrate preincubated with enzyme for 10 mins followed by substrate addition and measured after 30 to 60 mins by microplate reader analysis
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5110185
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 348.33 | 3.55 | 3.55 |
| 283.29 | 2.45 | 2.45 |
| 379.34 | 3.53 | 3.53 |
| 404.44 | 4.91 | 4.91 |
| 359.27 | 5.21 | 5.21 |
| 335.29 | 3.89 | 3.89 |
| 363.17 | 3.55 | 3.55 |
| 442.40 | 5.68 | 5.68 |
| 298.31 | 3.14 | 3.14 |
| 268.28 | 3.08 | 3.08 |
| 326.31 | 2.87 | 2.87 |
| 336.27 | 4.10 | 4.10 |
| 347.17 | 3.85 | 3.85 |
| 336.27 | 4.10 | 4.10 |
| 433.16 | 5.00 | 5.00 |
| 415.37 | 3.40 | 3.40 |
| 370.72 | 4.76 | 4.76 |
| 347.37 | 5.41 | 5.41 |
| 375.31 | 4.58 | 4.58 |
| 336.27 | 4.10 | 4.10 |
| 347.17 | 3.85 | 3.85 |
| 341.72 | 4.55 | 4.55 |
| 407.22 | 3.86 | 3.86 |
| 298.31 | 3.14 | 3.14 |
| 378.35 | 5.16 | 5.16 |
| 371.73 | 4.65 | 4.65 |
| 306.29 | 3.78 | 3.78 |
| 270.26 | 2.21 | 2.21 |
| 293.29 | 2.95 | 2.95 |
| 347.17 | 3.85 | 3.85 |
| 297.27 | 2.09 | 2.09 |
| 307.27 | 3.90 | 3.90 |
| 284.29 | 2.75 | 2.75 |
| 370.72 | 4.76 | 4.76 |
| 347.17 | 3.85 | 3.85 |
| 351.31 | 4.30 | 4.30 |
| 364.33 | 3.69 | 3.69 |
| 370.17 | 4.96 | 4.96 |