Basic Information
ID: ALA5111529
Type: Binding
Description: Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins followed by DNA and dNTP addition and measured after 120 mins by Picogreen dye fluorescence intensity analysis
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5111529
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 351.37 | 3.69 | 3.69 |
| 456.39 | 4.44 | 4.44 |
| 373.36 | 1.99 | 1.99 |
| 462.39 | 5.75 | 5.75 |
| 499.39 | 4.20 | 4.20 |
| 550.48 | 5.36 | 5.36 |
| 519.45 | 5.13 | 5.13 |
| 337.35 | 3.61 | 3.61 |
| 338.33 | 2.21 | 2.21 |
| 385.31 | 4.93 | 4.93 |
| 333.35 | 4.79 | 4.79 |
| 337.35 | 3.44 | 3.44 |
| 351.37 | 3.79 | 3.79 |
| 497.37 | 4.26 | 4.26 |
| 339.32 | 2.54 | 2.54 |
| 362.27 | 4.32 | 4.32 |
| 382.29 | 5.07 | 5.07 |
| 337.35 | 3.44 | 3.44 |
| 379.27 | 5.07 | 5.07 |
| 465.40 | 5.09 | 5.09 |
| 497.37 | 4.26 | 4.26 |
| 463.38 | 5.14 | 5.14 |
| 352.32 | 1.85 | 1.85 |
| 337.35 | 3.30 | 3.30 |
| 269.35 | 2.34 | 2.34 |
| 323.32 | 3.05 | 3.05 |
| 362.27 | 4.32 | 4.32 |
| 463.38 | 5.14 | 5.14 |
| 562.47 | 4.08 | 4.08 |
| 462.39 | 5.75 | 5.75 |
| 293.29 | 3.91 | 3.91 |
| 339.39 | 3.85 | 3.85 |
| 541.43 | 4.13 | 4.13 |
| 525.43 | 4.23 | 4.23 |
| 478.39 | 5.04 | 5.04 |
| 351.37 | 3.79 | 3.79 |
| 484.38 | 4.62 | 4.62 |
| 512.38 | 4.68 | 4.68 |
| 327.73 | 4.56 | 4.56 |
| 362.27 | 4.32 | 4.32 |
| 512.38 | 4.68 | 4.68 |
| 361.29 | 4.93 | 4.93 |
| 524.42 | 4.42 | 4.42 |
| 362.27 | 4.32 | 4.32 |
| 519.45 | 5.13 | 5.13 |
| 497.37 | 4.26 | 4.26 |
| 386.30 | 4.82 | 4.82 |
| 378.27 | 3.55 | 3.55 |