Basic Information
ID: ALA5113160
Type: Binding
Description: Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation using arachidonic acid as substrate preincubated with enzyme for 15 mins followed by substrate addition and measured after 10 mins by RP-HPLC analysis
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5113160
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 355.46 | 4.56 | 4.56 |
| 354.47 | 4.37 | 4.37 |
| 371.53 | 4.72 | 4.72 |
| 367.47 | 4.84 | 4.84 |
| 403.60 | 5.74 | 5.74 |
| 382.53 | 4.98 | 4.98 |
| 335.52 | 3.15 | 3.15 |
| 334.53 | 3.12 | 3.12 |
| 429.63 | 6.25 | 6.25 |
| 377.49 | 5.20 | 5.20 |
| 478.57 | 4.08 | 4.08 |
| 421.50 | 4.90 | 4.90 |
| 355.46 | 3.72 | 3.72 |
| 369.53 | 4.29 | 4.29 |
| 419.57 | 6.31 | 6.31 |
| 385.51 | 4.36 | 4.36 |
| 391.52 | 4.88 | 4.88 |
| 385.55 | 4.76 | 4.76 |
| 369.51 | 5.16 | 5.16 |
| 399.54 | 4.29 | 4.29 |
| 413.59 | 4.56 | 4.56 |