Basic Information
ID: ALA5118400
Type: Binding
Description: Antagonist activity at human P2X3R expressed in HEK293 cells assessed as reduction in alphabeta-MeATP-induced intracellular Ca2+ influx pretreated with compound followed by alphabeta-MeATP addition and measured by Fluo-4 dye fluorescence analysis
Organism: Homo sapiens
Cell type: HEK293
Activity Charts
Bioactivity
Activity Types for Assay ALA5118400
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 353.40 | 1.21 | 1.21 |
| 507.93 | 3.18 | 3.18 |
| 478.50 | 4.59 | 4.59 |
| 549.65 | 3.38 | 3.38 |
| 476.55 | 5.05 | 5.05 |
| 549.37 | 3.70 | 3.70 |
| 547.83 | 4.08 | 4.08 |
| 493.61 | 4.92 | 4.92 |
| 486.20 | 2.97 | 2.97 |
| 507.63 | 5.29 | 5.29 |
| 448.57 | 3.47 | 3.47 |
| 451.48 | 5.46 | 5.46 |
| 480.95 | 4.45 | 4.45 |
| 422.57 | 4.79 | 4.79 |
| 565.76 | 7.12 | 7.12 |
| 514.67 | 6.41 | 6.41 |
| 428.28 | 5.85 | 5.85 |
| 481.66 | 6.19 | 6.19 |
| 513.39 | 3.42 | 3.42 |
| 596.63 | 6.66 | 6.66 |
| 456.49 | 3.97 | 3.97 |