Assay Report Card

Basic Information

ID: ALA5119520

Type: ADME

Description: Induction of CYP3A4 in human hepatocytes assessed as fold induction at 1 uM using testosterone as substrate preincubated with replacement of fresh medium containing compound every 24 hrs for 72 hrs followed by substrate addition and measured after 1 hr by LC-MS/MS analysis relative to control

Organism: Homo sapiens

Cell type: Hepatocyte

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
569.685.315.31
530.625.725.72
576.695.995.99
597.745.955.95
590.605.755.75
555.665.005.00
592.694.964.96
580.674.874.87
569.685.315.31
583.715.565.56
623.656.026.02
588.706.136.13
575.674.704.70
562.675.605.60
603.685.605.60
531.614.824.82
576.695.995.99
576.695.995.99
576.695.995.99
574.685.605.60
590.105.655.65
518.615.725.72
526.615.265.26
575.674.704.70
539.614.364.36
566.654.834.83
569.685.315.31
554.555.415.41