Basic Information
ID: ALA5119521
Type: ADME
Description: Induction of CYP3A4 in human hepatocytes at 1 uM using testosterone as substrate preincubated with replacement of fresh medium containing compound every 24 hrs for 72 hrs followed by substrate addition and measured after 1 hr by LC-MS/MS analysis relative to rifampicin
Organism: Homo sapiens
Cell type: Hepatocyte
Activity Charts
Bioactivity
Activity Types for Assay ALA5119521
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 569.68 | 5.31 | 5.31 |
| 530.62 | 5.72 | 5.72 |
| 576.69 | 5.99 | 5.99 |
| 590.60 | 5.75 | 5.75 |
| 555.66 | 5.00 | 5.00 |
| 592.69 | 4.96 | 4.96 |
| 580.67 | 4.87 | 4.87 |
| 569.68 | 5.31 | 5.31 |
| 583.71 | 5.56 | 5.56 |
| 623.65 | 6.02 | 6.02 |
| 588.70 | 6.13 | 6.13 |
| 575.67 | 4.70 | 4.70 |
| 562.67 | 5.60 | 5.60 |
| 531.61 | 4.82 | 4.82 |
| 576.69 | 5.99 | 5.99 |
| 576.69 | 5.99 | 5.99 |
| 576.69 | 5.99 | 5.99 |
| 574.68 | 5.60 | 5.60 |
| 590.10 | 5.65 | 5.65 |
| 518.61 | 5.72 | 5.72 |
| 575.67 | 4.70 | 4.70 |
| 539.61 | 4.36 | 4.36 |
| 566.65 | 4.83 | 4.83 |
| 569.68 | 5.31 | 5.31 |
| 554.55 | 5.41 | 5.41 |