Basic Information
ID: ALA5120629
Type: Toxicity
Description: Inhibition of JAK2 signaling pathway in human CHEP cells assessed as inhibition of EPO-induced cell survival preincubated for 1 hr followed by EPO addition and measured after 48 hrs by CellTiter-Glo luminescent assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: CHEP
Target: Tyrosine-protein kinase JAK2(ALA2971)
Document: ALA5113550
Inhibition of JAK2 signaling pathway in human CHEP cells assessed as inhibition of EPO-induced cell survival preincubated for 1 hr followed by EPO addition and measured after 48 hrs by CellTiter-Glo luminescent assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA5120629
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 395.39 | 4.16 | 4.16 |
| 395.39 | 4.18 | 4.18 |
| 431.37 | 4.73 | 4.73 |
| 377.40 | 4.02 | 4.02 |
| 407.43 | 4.03 | 4.03 |
| 391.43 | 4.33 | 4.33 |
| 431.37 | 4.73 | 4.73 |
| 423.43 | 3.73 | 3.73 |
| 393.40 | 3.72 | 3.72 |
| 419.34 | 4.86 | 4.86 |
| 432.49 | 2.85 | 2.85 |
| 413.38 | 4.65 | 4.65 |