Basic Information
ID: ALA5120630
Type: Binding
Description: Selectivity ratio of IC50 for inhibition of JAK2 signaling pathway in EPO-stimulated human CHEP cells to IC50 for inhibition of JAK1/JAK3 in human primary T-cells assessed as reduction of IL-2 stimulated STAT5 phosphorylation
Format: BAO_0000019
Organism: Homo sapiens
Target: Unchecked(ALA612545)
Document: ALA5113550
Selectivity ratio of IC50 for inhibition of JAK2 signaling pathway in EPO-stimulated human CHEP cells to IC50 for inhibition of JAK1/JAK3 in human primary T-cells assessed as reduction of IL-2 stimulated STAT5 phosphorylation: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA5120630
Ratio IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 395.39 | 4.16 | 4.16 |
| 395.39 | 4.18 | 4.18 |
| 431.37 | 4.73 | 4.73 |
| 377.40 | 4.02 | 4.02 |
| 407.43 | 4.03 | 4.03 |
| 391.43 | 4.33 | 4.33 |
| 431.37 | 4.73 | 4.73 |
| 423.43 | 3.73 | 3.73 |
| 393.40 | 3.72 | 3.72 |
| 419.34 | 4.86 | 4.86 |
| 432.49 | 2.85 | 2.85 |
| 413.38 | 4.65 | 4.65 |