Basic Information
ID: ALA5123054
Type: Binding
Description: Inhibition of recombinant human Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3)pLysS cells/Nrf2 (unknown origin) protein-protein interaction using FITC-LDEETGEFL-NH2 as fluorescent substrate preincubated with compound for 30 mins followed by substrate addition and measured after 1 hr by fluorescence polarization assay relative to control
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5123054
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 614.65 | 3.42 | 3.42 |
| 712.82 | 5.82 | 5.82 |
| 671.71 | 3.24 | 3.24 |
| 746.66 | 5.86 | 5.86 |
| 706.75 | 5.21 | 5.21 |
| 684.75 | 4.15 | 4.15 |
| 700.74 | 3.85 | 3.85 |
| 670.72 | 3.84 | 3.84 |
| 656.69 | 4.06 | 4.06 |
| 762.86 | 7.16 | 7.16 |
| 640.69 | 3.93 | 3.93 |
| 720.78 | 5.00 | 5.00 |
| 762.82 | 5.63 | 5.63 |
| 656.71 | 4.58 | 4.58 |
| 706.77 | 5.73 | 5.73 |
| 646.65 | 4.10 | 4.10 |
| 768.46 | 5.35 | 5.35 |
| 780.82 | 6.30 | 6.30 |
| 704.77 | 3.84 | 3.84 |
| 686.74 | 4.59 | 4.59 |
| 670.72 | 3.84 | 3.84 |
| 688.71 | 3.98 | 3.98 |
| 638.72 | 4.44 | 4.44 |
| 746.82 | 5.51 | 5.51 |
| 683.76 | 3.90 | 3.90 |
| 714.82 | 6.11 | 6.11 |
| 698.77 | 4.28 | 4.28 |
| 647.73 | 3.25 | 3.25 |
| 684.76 | 5.36 | 5.36 |
| 732.79 | 5.72 | 5.72 |
| 686.74 | 4.59 | 4.59 |
| 720.78 | 5.00 | 5.00 |
| 684.75 | 3.89 | 3.89 |
| 688.78 | 5.60 | 5.60 |
| 638.72 | 4.44 | 4.44 |