Basic Information
ID: ALA5123442
Type: Binding
Description: Protac activity at CRBN E3 ligase/FAK in human A549 cells assessed as induction of FAK protein degradation at 10 nM preincubated with FAK inhibitor TAE-226 for 2 hrs followed by compound addition and measured after 12 hrs by Western blot analysis
Format: BAO_0000219
Organism: Homo sapiens
Cell type: A549
Target: Cereblon/Focal adhesion kinase 1(ALA4680052)
Document: ALA5120849
Protac activity at CRBN E3 ligase/FAK in human A549 cells assessed as induction of FAK protein degradation at 10 nM preincubated with FAK inhibitor TAE-226 for 2 hrs followed by compound addition and measured after 12 hrs by Western blot analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA5123442
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 823.31 | 4.32 | 4.32 |