Basic Information
ID: ALA5124218
Type: ADME
Description: Inhibition of CYP3A in human liver microsomes at 10 uM preincubated for 5 mins in presence of NADPH-generating system followed by midazolam substrate addition and measured after 10 mins by HPLC-MS/MS analysis relative to control
Format: BAO_0000251
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsome
Target: Unchecked(ALA612545)
Document: ALA5120869
Inhibition of CYP3A in human liver microsomes at 10 uM preincubated for 5 mins in presence of NADPH-generating system followed by midazolam substrate addition and measured after 10 mins by HPLC-MS/MS analysis relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA5124218
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 475.64 | 5.07 | 5.07 |
| 476.62 | 4.47 | 4.47 |
| 490.65 | 4.60 | 4.60 |
| 434.54 | 3.30 | 3.30 |
| 532.73 | 5.77 | 5.77 |