Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate preincubated for 5 mins followed by NADPH addition measured after 10 mins...

Basic Information

ID: ALA5125553

Type: ADME

Description: Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate preincubated for 5 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysis

Format: BAO_0000251

Organism: Homo sapiens

Tissue: Liver

Subcellular Fraction: Microsome

Target: Cytochrome P450 2C8(ALA3721)

Document: ALA5120931

Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate preincubated for 5 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysis: 1

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA5125553

IC50

Total(2)

Parent Molecular Weight	ALogP	Polar Surface Area
400.50	2.82	2.82
412.51	2.96	2.96

Parent Molecular Weight

ALogP

Polar Surface Area

400.50

2.82

412.51

2.96

Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate preincubated for 5 mins followed by NADPH addition measured after 10 mins...

Basic Information

Activity Charts

Compound Summary