Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate preincubated for 5 mins followed by NADPH addition measured after 20 min...

Basic Information

ID: ALA5125556

Type: ADME

Description: Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate preincubated for 5 mins followed by NADPH addition measured after 20 mins by LC-MS/MS analysis

Format: BAO_0000251

Organism: Homo sapiens

Tissue: Liver

Subcellular Fraction: Microsome

Target: Cytochrome P450 2C9(ALA3397)

Document: ALA5120931

Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate preincubated for 5 mins followed by NADPH addition measured after 20 mins by LC-MS/MS analysis: 1

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA5125556

IC50

Total(2)

Parent Molecular Weight	ALogP	Polar Surface Area
400.50	2.82	2.82
412.51	2.96	2.96

Parent Molecular Weight

ALogP

Polar Surface Area

400.50

2.82

412.51

2.96

Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate preincubated for 5 mins followed by NADPH addition measured after 20 min...

Basic Information

Activity Charts

Compound Summary