Basic Information
ID: ALA5126027
Type: Functional
Description: Antagonist activity at human MRGPRX2 expressed in HEK293 cells co-expressing mouse Galpha15 assessed as inhibition of Cortistatin-14 induced Ca2+ mobilization preincubated for 30 mins followed by Cortistatin-14 addition by FLIPRtetra-calcium mobilization assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HEK293
Target: Mas-related G-protein coupled receptor member X2(ALA5849)
Document: ALA5120954
Antagonist activity at human MRGPRX2 expressed in HEK293 cells co-expressing mouse Galpha15 assessed as inhibition of Cortistatin-14 induced Ca2+ mobilization preincubated for 30 mins followed by Cortistatin-14 addition by FLIPRtetra-calcium mobilization assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA5126027
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 507.90 | 4.20 | 4.20 |
| 491.45 | 3.63 | 3.63 |
| 471.48 | 5.50 | 5.50 |
| 483.52 | 3.47 | 3.47 |
| 545.56 | 3.24 | 3.24 |
| 582.58 | 3.84 | 3.84 |